Fig. 3 | Metabolic Brain Disease

Fig. 3

From: Correction to: Role of PUMA in the methamphetamine-induced migration of microglia

Fig. 3

The MAPK and PI3K/Akt pathways were involved in the methamphetamine-induced up-regulation of PUMA in microglia. a, b Representative western blot showing the effects of methamphetamine on the increase in PUMA expression, which was attenuated by the MAPK inhibitor (SB203580, 10 μM), the JNK inhibitor (SP600125, 10 μM) and the PI3K/Akt inhibitor (LY294002, 10 μM) but not the ERK inhibitor (U0126, 10 μM) in BV2 and HAPI cells. c, d Densitometric analyses suggested that methamphetamine increased PUMA expression, which was attenuated by the SB203580, SP600125 and LY294002 pretreatments but not the U0126 pretreatment. * p < 0.05, ** p < 0.01 vs the control group; ## p < 0.01 vs the methamphetamine-treated group using one-way ANOVA. Meth, methamphetamine

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