Metabolic Brain Disease

, Volume 33, Issue 3, pp 713–724 | Cite as

The effects of vitamin E on brain derived neurotrophic factor, tissues oxidative damage and learning and memory of juvenile hypothyroid rats

  • Yousef Baghcheghi
  • Farimah Beheshti
  • Mohammad Naser Shafei
  • Hossein Salmani
  • Hamid Reza Sadeghnia
  • Mohammad Soukhtanloo
  • Akbar Anaeigoudari
  • Mahmoud Hosseini
Original Article


The effects of vitamin E (Vit E) on brain derived neurotrophic factor (BDNF) and brain tissues oxidative damage as well as on learning and memory impairments in juvenile hypothyroid rats were examined. The rats were grouped as: (1) Control; (2) Propylthiouracil (PTU); (3) PTU-Vit E and (4) Vit E. PTU was added to their drinking water (0.05%) during 6 weeks. Vit E (20 mg/kg) was daily injected (IP). Morris water maze (MWM) and passive avoidance (PA) were carried out. The animals were deeply anesthetized and the brain tissues were removed for biochemical measurements. PTU increased the escape latency and traveled path in MWM (P < 0.001). It also shortened the latency to enter the dark compartment of PA as well as the time spent in the target quadrant in probe trial of MWM (P < 0.01-P < 0.001). All the effects of PTU were reversed by Vit E (P < 0.01-P < 0.001). PTU administration attenuated thiol and BDNF content as well as the activities of superoxide dismutase (SOD) and catalase (CAT) in the brain tissues while increased molondialdehyde (MDA). Moreover, Vit E improved BDNF, thiol, SOD and CAT while diminished MDA. The results of the present study showed that Vit E improved BDNF and prevented from brain tissues oxidative damage as well as learning and memory impairments in juvenile hypothyroid rats.


Hypothyroidism Learning Memory BDNF Oxidative stress Vitamin E 



Authors would like to thank the Vice President of Research in Mashhad University of Medical Sciences for the financial support.

Compliance with ethical standards

Conflict of interest

The authors declare that there is no conflict of interest.


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Authors and Affiliations

  • Yousef Baghcheghi
    • 1
  • Farimah Beheshti
    • 2
  • Mohammad Naser Shafei
    • 3
  • Hossein Salmani
    • 4
  • Hamid Reza Sadeghnia
    • 5
  • Mohammad Soukhtanloo
    • 6
  • Akbar Anaeigoudari
    • 7
  • Mahmoud Hosseini
    • 2
  1. 1.Student Research Committee, Department of Physiology, Faculty of MedicineMashhad University of Medical SciencesMashhadIran
  2. 2.Division of Neurocognitive Sciences, Psychiatry and Behavioral Sciences Research CenterMashhad University of Medical SciencesMashhadIran
  3. 3.Neurogenic Inflammation Research CenterMashhad University of Medical SciencesMashhadIran
  4. 4.Department of Physiology, Faculty of MedicineMashhad University of Medical SciencesMashhadIran
  5. 5.Pharmacological Research Center of Medicinal PlantsMashhad University of Medical SciencesMashhadIran
  6. 6.Department of Biochemistry, Faculty of MedicineMashhad University of Medical SciencesMashhadIran
  7. 7.Department of Physiology, School of MedicineJiroft University of Medical SciencesJiroftIran

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