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Metabolic Brain Disease

, Volume 33, Issue 3, pp 637–645 | Cite as

Association between PDE4D rs966221 polymorphism and risk of ischemic stroke: a systematic review and meta-analysis

  • Peng Wang
  • Fei Yang
  • Cai Xiang Liu
  • Yan Min Wu
  • Chen Gu
  • Hua Jian Zhu
Review Article
  • 132 Downloads

Abstract

PDE4D polymorphism (SNP83/rs966221) was reported to be associated with the susceptibility to ischemic stroke (IS), however, the results were inconclusive. An electronic search of Embase, PubMed, CNKI and Wan Fang Date was performed to identify relevant studies published throughout April 2017. A total of 26 studies were enrolled in the analysis. No significant association between the rs9662221 polymorphism and IS was observed in the overall analysis. Nevertheless, in the subgroup analysis, our results showed a significant association between the SNP83 polymorphism and IS in CC+ CT vs. TT (OR = 1.19, 95% CI: 1.02–1.38), CT vs.TT (OR = 1.14, 95% CI: 1.01–1.29) and C vs. T (OR = 1.25, 95% CI: 1.06–1.48) in Asian population. But we did not found any association in CC vs. CT + TT (OR = 1.2, 95% CI: 0.9–1.61) and CC vs. TT (OR = 1.26, 95% CI: 0.91–1.75) in the Asian populations. Meantime, no significant correlations were observed under the five genetic model in Caucasian population (p > 0.05). In conclusion, our meta-analysis demonstrated that the SNP83 polymorphism in the PDE4D gene might contribute to IS susceptibility especially in Asian populations. Whereas the relationship of the polymorphism to the disease in Caucasian population was still in controversial. In future, additional well designed studies with larger sample sizes are still required to further elucidate this association.

Keywords

PDE4D Ischemic stroke Polymorphism SNP83 rs9662221 

Notes

Acknowledgements

This work was supported by Wu Xi Health Technology Project (YGM1125).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

References

  1. Bak S, Gaist D, Sindrup SH, Skytthe A, Christensen K (2002) Genetic liability in stroke: a long-term follow-up study of Danish twins. Stroke 33:769–774.  https://doi.org/10.1161/hs0302.103619 CrossRefPubMedGoogle Scholar
  2. Banerjee I, Gupta V, Ahmed T, Faizaan M, Agarwal P, Ganesh S (2008) Inflammatory system gene polymorphism and the risk of stroke: a case–control study in an Indian population. Brain Res Bull 75:158–165.  https://doi.org/10.1016/j.brainresbull.2007.08.007 CrossRefPubMedGoogle Scholar
  3. Cheng H, Jin Q, Li L, Ding X, Song X, Zeng Y (2011) Association of ALOX5AP and PDE4D with the risk of lacunar infarct in people from Jiangsu Province, China. China Nerve Regeneration Research 6:935–940Google Scholar
  4. Das S, Roy S, Munshi A (2016) Association between PDE4D gene and ischemic stroke: recent advancements. Int J Neurosci 126:577–583.  https://doi.org/10.3109/00207454.2015.1051621 PubMedCrossRefGoogle Scholar
  5. Gretarsdottir S, Thorleifsson G, Reynisdottir ST, Manolescu A, Jonsdottir S, Jonsdottir T, Gudmundsdottir T, Bjarnadottir SM, Einarsson OB, Gudjonsdottir HM, Hawkins M, Gudmundsson G, Gudmundsdottir H, Andrason H, Gudmundsdottir AS, Sigurdardottir M, Chou TT, Nahmias J, Goss S, Sveinbjörnsdottir S, Valdimarsson EM, Jakobsson F, Agnarsson U, Gudnason V, Thorgeirsson G, Fingerle J, Gurney M, Gudbjartsson D, Frigge ML, Kong A, Stefansson K, Gulcher JR (2003) The gene encoding phosphodiesterase 4D confers risk of ischemic stroke. Nat Genet 35:131–138.  https://doi.org/10.1038/ng1245 CrossRefPubMedGoogle Scholar
  6. Jianhua PJ, Zhang X (2012) Relationship between SNP 83 of phosphodiesterase 4D gene and ischemic cerebrovascular diseases in Xinjiang Uygur and Han population. Chinese Journal of Nervous and Mental Diseases 38:733–737Google Scholar
  7. Jorgensen C, Yasmeen S, Iversen HK, Kruuse C (2015) Phosphodiesterase4D (PDE4D)--a risk factor for atrial fibrillation and stroke? J Neurol Sci 359:266–274.  https://doi.org/10.1016/j.jns.2015.11.010 CrossRefPubMedGoogle Scholar
  8. Kalita J, Somarajan BI, Kumar B, Kumar S, Mittal B, Misra UK (2011) Phosphodiesterase 4 D gene polymorphism in relation to intracranial and extracranial atherosclerosis in ischemic stroke. Dis Markers 31:191–197.  https://doi.org/10.1155/2011/232490 CrossRefPubMedPubMedCentralGoogle Scholar
  9. Kotlęga D, Peda B, Zembroń-Łacny A, Gołąb-Janowska M, Nowacki P (2017) The role of brain-derived neurotrophic factor and its single nucleotide polymorphisms in stroke patients. Neurol Neurochir Pol 51(3):240–246.  https://doi.org/10.1016/j.pjnns.2017.02.008
  10. Kuhlenbaumer G et al (2006) Evaluation of single nucleotide polymorphisms in the phosphodiesterase 4D gene (PDE4D) and their association with ischaemic stroke in a large German cohort. J Neurol Neurosurg Psychiatry 77:521–524.  https://doi.org/10.1136/jnnp.2005.073577 CrossRefPubMedPubMedCentralGoogle Scholar
  11. Li N, He Z, Xu J, Liu F, Deng S, Zhang H (2010) Association of PDE4D and IL-1 gene polymorphism with ischemic stroke in a Han Chinese population. Brain Res Bull 81:38–42.  https://doi.org/10.1016/j.brainresbull.2009.09.009 CrossRefPubMedGoogle Scholar
  12. Lin HF, Liao YC, Liou CW, Liu CK, Juo S (2007) The phosphodiesterase 4D gene for early onset ischemic stroke among normotensive patients. Journal of thrombosis. Haemostasis 5:436–438.  https://doi.org/10.1111/j.1538-7836.2007.02350.x CrossRefGoogle Scholar
  13. Liu K, Wang JW, Yu ZP, Qin XY, Wu YQ, Li N, Kui YQ, Fang K, Wang XY, Wu T, Chen DF, Hu YH (2013) Association study between PDE4D gene polymorphism and ischemic stroke. Beijing Da Xue Xue Bao 45:359–363PubMedGoogle Scholar
  14. Luo M et al (2014) Relation between phosphodiesterase 4D gene polymorphism and ischemic stroke in Guangdong Han population. Chinese journal of geriatric heart brain and vessel. Diseases 16:503–506Google Scholar
  15. Matsushita T, Kubo M, Yonemoto K, Ninomiya T, Ashikawa K, Liang B, Hata J, Doi Y, Kitazono T, Ibayashi S, Iida M, Kiyohara Y, Nakamura Y et al (2009) Lack of association between variations of PDE4D and ischemic stroke in the Japanese population. Stroke 40:1245–1251.  https://doi.org/10.1161/STROKEAHA.108.527408 CrossRefPubMedGoogle Scholar
  16. Meschia JF, Brott TG, Brown RD Jr, Crook R, Worrall BB (2005) Phosphodiesterase 4D and 5-lipoxygenase activating protein in ischemic stroke. Ann Neurol 58:351–361.  https://doi.org/10.1002/ana.20585 CrossRefPubMedPubMedCentralGoogle Scholar
  17. Mika D, Conti M (2016) PDE4D phosphorylation: a coincidence detector integrating multiple signaling pathways. Cell Signal 28:719–724.  https://doi.org/10.1016/j.cellsig.2015.11.001 CrossRefPubMedGoogle Scholar
  18. Munshi A, Kaul S (2008) Stroke genetics--focus on PDE4D gene. Int J Stroke 3:188–192.  https://doi.org/10.1111/j.1747-4949.2008.00199.x CrossRefPubMedGoogle Scholar
  19. Munshi A, Babu MS, Kaul S, Shafi G, Anila AN, Alladi S, Jyothy A et al (2009) Phosphodiesterase 4D (PDE4D) gene variants and the risk of ischemic stroke in a south Indian population. J Neurol Sci 285:142–145.  https://doi.org/10.1016/j.jns.2009.06.024 CrossRefPubMedGoogle Scholar
  20. Quarta G, Stanzione R, Evangelista A, Zanda B, Angelantonio ED (2009) Phosphodiesterase 4D and 5-lipoxygenase activating protein genes and risk of ischemic stroke in Sardinians. Eur J Hum Genet 17:1448–1453.  https://doi.org/10.1038/ejhg.2009.71 CrossRefPubMedPubMedCentralGoogle Scholar
  21. Saleheen D, Bukhari S, Haider SR, Nazir A, Khanum S, Shafqat S, Anis MK, Frossard P et al (2005) Association of Phosphodiesterase 4D gene with ischemic stroke in a Pakistani population. Stroke 36:2275–2277.  https://doi.org/10.1161/01.STR.0000182242.59466.ee CrossRefPubMedGoogle Scholar
  22. Shao M, Yi X, Chi L, Lin J, Zhou Q, Huang R (2015) Ischemic stroke risk in a southeastern Chinese population: insights from 5-lipoxygenase activating protein and phosphodiesterase 4D single-nucleotide polymorphisms. J Formos Med Assoc 114:422–429.  https://doi.org/10.1016/j.jfma.2013.12.004 CrossRefPubMedGoogle Scholar
  23. Song Q (2006) Phosphodiesterase 4D polymorphisms and the risk of cerebral infarction in a biracial population: the stroke prevention in young women study. Hum Mol Genet 15:2468–2478.  https://doi.org/10.1093/hmg/ddl169 CrossRefPubMedPubMedCentralGoogle Scholar
  24. Song HJ, Zhou XH, Guo L, Tian FL, Guo XF, Sun YX (2015) Association of phosphodiesterase 4D gene and interleukin-6 receptor gene polymorphisms with ischemic stroke in a Chinese hypertensive population. Genet Mol Res 14:19396–19403.  https://doi.org/10.4238/2015.December.29.50 CrossRefPubMedGoogle Scholar
  25. Song YL et al (2017) Phosphodiesterase 4D polymorphisms associate with the short-term outcome in ischemic stroke. Sci Rep 7:42914.  https://doi.org/10.1038/srep42914 CrossRefPubMedPubMedCentralGoogle Scholar
  26. Staton JM, Sayer MS, Hankey GJ, Attia J, Thakkinstian A (2006) Association between phosphodiesterase 4D gene and ischaemic stroke. Journal of Neurology Neurosurgery Psychiatry 77:1067–1069.  https://doi.org/10.1136/jnnp.2006.092106 CrossRefGoogle Scholar
  27. Sun Y, Huang Y, Chen X, Liu Y, Lu X (2009) Association between the PDE4D gene and ischaemic stroke in the Chinese Han population. Clin Sci 117:265–272.  https://doi.org/10.1042/CS20080471 CrossRefPubMedGoogle Scholar
  28. van Rijn MJ et al (2005) Familial aggregation, the PDE4D gene, and ischemic stroke in a genetically isolated population. Neurology 65:1203–1209.  https://doi.org/10.1212/01.wnl.0000178744.42953.b7 CrossRefPubMedGoogle Scholar
  29. Wang HM, Chen XL, Ye HH, Bi Y, Pan DB, Xu LY et al (2012) Association ot phosphodiesterase 4D gene with Atherothrombosis ischemic Strok. J Med Res 41:134–137Google Scholar
  30. Wang X, Sun Z, Zhang Y, Tian X, Li Q, Luo J (2017) Impact of the PDE4D gene polymorphism and additional SNP-SNP and gene-smoking interaction on ischemic stroke risk in Chinese Han population. Neurol Res 39(4):351–356.  https://doi.org/10.1080/01616412.2017.1289309
  31. Woo D, Kaushal R, Kissela B, Sekar P, Wolujewicz M, Pal P, Alwell K, Haverbusch M, Ewing I, Miller R, Kleindorfer D, Flaherty M, Chakraborty R, Deka R, Broderick J et al (2006) Association of Phosphodiesterase 4D with ischemic stroke: a population-based case-control study. Stroke 37:371–376.  https://doi.org/10.1161/01.STR.0000198843.72824.0a CrossRefPubMedGoogle Scholar
  32. Xu S, Zhang Y, Lin X (2008) Relationship between phosphodiesterase 4D gene polymorphism and ischemic cerebral vascular disease. J clin Neurol 21:249–252Google Scholar
  33. Xue H, Wang H, Song X, Li W, Sun K, Zhang W, Wang X, Wang Y, Hui R (2009) Phosphodiesterase 4D gene polymorphism is associated with ischaemic and haemorrhagic stroke. Clin Sci (Lond) 116(4):335–340.  https://doi.org/10.1042/CS20080162 CrossRefGoogle Scholar
  34. Yan Y, Luo X, Zhang J, Su L, Liang W, Huang G, Wu G, Huang G, Gu L et al (2014) Association between phosphodiesterase 4D polymorphism SNP83 and ischemic stroke. J Neurol Sci 338:3–11.  https://doi.org/10.1016/j.jns.2013.12.012 CrossRefPubMedGoogle Scholar
  35. Yang F, Liu S, Yu C, Wang SJ, Paganini-Hill A, Fisher MJ (2012) PDE4 regulates tissue plasminogen activator expression of human brain microvascular endothelial cells. Thromb Res 129:750–753.  https://doi.org/10.1016/j.thromres.2011.12.008 CrossRefPubMedPubMedCentralGoogle Scholar
  36. Yoon D, Park SK, Kang D, Park T, Park JW (2011) Meta-analysis of homogeneous subgroups reveals association between PDE4D gene variants and ischemic stroke. Neuroepidemiology 36:213–222.  https://doi.org/10.1159/000327915 CrossRefPubMedGoogle Scholar
  37. Zhang HL, Wang SR, Li SM (2009) Study on association of the single nucleotide polymorphism of phosphodiesterase 4D with stroke. J Chin Microcirc 13:624–627Google Scholar
  38. Zhang S, Wang XB, Han YD, Wang C, Zhou Y, Zheng F (2017) Certain polymorphisms in SP110 gene confer susceptibility to tuberculosis: a comprehensive review and updated meta-analysis. Yonsei Med J 58:165–173.  https://doi.org/10.3349/ymj.2017.58.1.165 CrossRefPubMedGoogle Scholar
  39. Zhao J, Wang X, Xu J, Li N, Shang X, He Z, Yang J (2012) Association of inflammatory response gene polymorphism with atherothrombotic stroke in Northern Han Chinese. Acta Biochim Biophys Sin (Shanghai) 44(12):1023–1030.  https://doi.org/10.1093/abbs/gms088

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2017

Authors and Affiliations

  • Peng Wang
    • 1
  • Fei Yang
    • 1
  • Cai Xiang Liu
    • 2
  • Yan Min Wu
    • 3
  • Chen Gu
    • 1
  • Hua Jian Zhu
    • 4
  1. 1.Intervertional Radiology and Vascular DepartmentThe Third Affiliated Hospital of Nantong UniversityWuxiChina
  2. 2.Nephrology DepartmentWuxi Hospital of Traditional Chinese MedicineWuxiChina
  3. 3.Gastroenterology DepartmentThe Third Affiliated Hospital of Nantong UniversityWuxiChina
  4. 4.Surgery of Traditional Chinese MedicineThe Third Affiliated Hospital of Nantong UniversityWuxiChina

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