Metabolic Brain Disease

, Volume 33, Issue 2, pp 559–568 | Cite as

Social cognition and aggression in methamphetamine dependence with and without a history of psychosis

  • Anne Uhlmann
  • Jonathan C. Ipser
  • Don Wilson
  • Dan J. Stein
Original Article

Abstract

In substance use and psychotic disorders, socially problematic behaviours, such as high aggression may, in part, be explained by deficits in social cognition skills, like the detection of emotions or intentions in others. The aim of this study was to assess the magnitude of social cognition impairment and its association with aggression in individuals with methamphetamine (MA) dependence, methamphetamine-associated psychosis (MAP), and healthy controls (CTRL). A total of 20 MAP participants, 21 MA-dependent participants without psychosis, and 21 CTRL participants performed a facial morphing emotion recognition task (ERT) across four basic emotions (anger, fear, happiness and sadness) and the reading the mind in the eyes task (RMET), and completed the aggression questionnaire. Both MA-dependent groups showed impairment in social cognition in terms of lower RMET scores relative to CTRL participants (MA; p = .047; MAP: p < .001). Additionally, performance decrements were significantly greater in MAP (p = .040), compared to MA-dependent participants. While deficits in recognising emotional expressions were restricted to anger in the MA group (p = .020), a generalized impairment across all four emotions was observed in MAP (all p ≤ .001). Additionally, both patient groups demonstrated higher levels of aggression than CTRLs, yet no association was found with social cognition. This study supported the notion of deficits in recognising facial emotional expressions and inferring mental states of others in MA dependence, with additional impairments in MAP. Failure to detect an association between social cognitive impairment and aggressive behaviour may implicate independent disturbances of the two phenomena in MA dependence.

Keywords

Theory of mind Affect regulation Emotion recognition Anger Psychostimulant abuse 

Notes

Acknowledgements

This work has been funded by grants from the Medical Research Council of South Africa (MRC).

Compliance with ethical standards

Conflict of interest

Dr. Stein has received research grants and/or consultancy honoraria from Abbott, ABMRF, Astrazeneca, Biocodex, Eli-Lilly, GlaxoSmithKline, Jazz Pharmaceuticals, Johnson & Johnson, Lundbeck, National Responsible Gambling Foundation, Novartis, Orion, Pfizer, Pharmacia, Roche, Servier, Solvay, Sumitomo, Sun, Takeda, Tikvah, and Wyeth. All other authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2017

Authors and Affiliations

  1. 1.Department of Psychiatry and Mental HealthUniversity of Cape TownCape TownSouth Africa
  2. 2.Department of PsychiatryStellenbosch UniversityCape TownSouth Africa
  3. 3.MRC Unit on Risk and Resilience in Mental DisordersUniversity of Cape TownCape TownSouth Africa

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