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Metabolic Brain Disease

, Volume 33, Issue 2, pp 359–368 | Cite as

Neuroscience in Nigeria: the past, the present and the future

  • Wasiu Gbolahan Balogun
  • Ansa Emmanuel Cobham
  • Abdulbasit Amin
Original Article

Abstract

The science of the brain and nervous system cuts across almost all aspects of human life and is one of the fastest growing scientific fields worldwide. This necessitates the demand for pragmatic investment by all nations to ensure improved education and quality of research in Neurosciences. Although obvious efforts are being made in advancing the field in developed societies, there is limited data addressing the state of neuroscience in sub-Saharan Africa. Here, we review the state of neuroscience development in Nigeria, Africa’s most populous country and its largest economy, critically evaluating the history, the current situation and future projections. This review specifically addresses trends in clinical and basic neuroscience research and education. We conclude by highlighting potentially helpful strategies that will catalyse development in neuroscience education and research in Nigeria, among which are an increase in research funding, provision of tools and equipment for training and research, and upgrading of the infrastructure at hand.

Keywords

Nigeria Neuroscience Funding History Research 

Notes

Acknowledgements

BWG is grateful to USM and TWAS for the award of doctorate fellowship, CAE is grateful to Monash University for the award of Dean Scholarship, AA is grateful to IGC for the doctorate fellowship.

Compliance with ethical standards

Conflict of interest

The authors declared no conflict of interest.

References

  1. Abcam (2015). Abcam signs exclusive partnership agreement with A*STAR's Institute of Molecular and Cell Biology. Available from http://www.abcam.com/index.html?pageconfig=news&rid=16557/
  2. Abd-Allah F, Kissani N, William A, Oraby MI, Moustafa RR, Shaker E, El-Tamawy MS, Shakir R (2016) Neuroscience research in Africa: current status. eNeurologicalSci 3:7–10CrossRefPubMedGoogle Scholar
  3. Adesulu D (2016). FG urged to reduce criteria for accessing TETFUND. Available from http://www.vanguardngr.com/2016/09/fg-urged-reduce-criteria-accessing-tetfund/
  4. Adewuya AO, Makanjuola ROA (2008) Social distance towards people with mental illness in southwestern Nigeria. Aust N Z J Psychiatry 42(5):389–395CrossRefPubMedGoogle Scholar
  5. Adewuya AO, Makanjuola ROA (2009) Preferred treatment for mental illness among southwestern Nigerians. Psychiatr Serv 60(1):121–124CrossRefPubMedGoogle Scholar
  6. Agaku I, Akinyele A, Oluwafemi A (2012) Tobacco control in Nigeria-policy recommendations. Tob Induc Dis 10:8CrossRefPubMedPubMedCentralGoogle Scholar
  7. Aghukwa CN (2012) Care seeking and beliefs about the cause of mental illness among Nigerian psychiatric patients and their families. Psychiatr Serv 63(6):616–618CrossRefPubMedGoogle Scholar
  8. Ahmad K (2001) Drug company sued over research trial in Nigeria. Lancet 358(9284):815CrossRefPubMedGoogle Scholar
  9. Akil H, Balice-Gordon R, Cardozo DL, Koroshetz W, Norris SMP, Sherer T, Sherman SM, Thiels E (2016) Neuroscience training for the 21st century. Neuron 90(5):917–926CrossRefPubMedGoogle Scholar
  10. Akinyemi RO, Okubadejo NN, Akinyemi JO, Owolabi MO, Owolabi LF, Ogunniyi A (2008) Cognitive dysfunction in Nigerians with Parkinson's disease. Mov Disord 23(10):1378–1383CrossRefPubMedGoogle Scholar
  11. Atilola O, Ayinde O (2015) A cultural look on suicide: the Yorùbá as a paradigmatic example. Ment Health Relig Cult 18(6):456–469CrossRefGoogle Scholar
  12. Babalola OE, Amoni SS, Samaila E, Darougar S (1990) An outbreak of acute haemorrhagic conjunctivitis in Kaduna, Nigeria. Br J Ophthalmol 74:89–92CrossRefPubMedPubMedCentralGoogle Scholar
  13. Binite A, Olisa V and Tanba S (2016). Tackling menace of drug abuse in Nigeria. Available from https://guardian.ng/features/weekend/tackling-menace-of-drug-abuse-in-nigeria/
  14. Bogic M, Njoku A, Priebe S (2015) Long-term mental health of war-refugees: a systematic literature review. BMC Int Health Hum Rights 28(15):29CrossRefGoogle Scholar
  15. Brown RE (2016) Seven steps to setting up a neuroscience program in a developing country in: Pfaff DW, Volkow ND (Eds.) neuroscience in the 21st century from basic to clinical springer. N Y 2:4087–4114Google Scholar
  16. Caxton-Martins EA (1996). Of Histochemistry: the growing science. Inaugural lecture series in: Adepetu JA, Ebigbola JA, Ogedengbe MO (Eds), Africa and the Middle East: the politics of asymmetry, Obafemi Awolowo University press limited, Vol. 115–121Google Scholar
  17. Chikezie UE, Otakpor AN, Kuteyi OB, James BO (2012) Suicidality among individuals with HIV/AIDS in Benin City, Nigeria: a case-control study. Psychol Socio-med Aspects of AIDS/HIV 24(7):843–845CrossRefGoogle Scholar
  18. Chow J, Uadiale K, Bestman A, Kamau C, Caugant DA, Shehu A, Greig J (2016) Invasive meningococcal meningitis serogroup C outbreak in Northwest Nigeria, 2015 – third consecutive outbreak of a new strain. PLoS Curr 8.  https://doi.org/10.1371/currents.outbreaks.06d10b6b4e690917d8b0a04268906143
  19. Clemons K, Kretsch A, Verbeck G (2014) Parallel artificial membrane permeability assay for blood-brain permeability determination of illicit drugs and synthetic analogues. Sci Just J Forensic Sci Soc 54(5):351–355CrossRefGoogle Scholar
  20. Eferakeya AE (1984) Drugs and suicide attempts in Benin City, Nigeria. Br J Psychiatry 145(1):70–73CrossRefPubMedGoogle Scholar
  21. Elufioye TO, Oladele AT, Cyril-Olutayo CM, Agbedahunsi JM, Adesanya SA (2012) Ethnomedicinal study and screening of plants used for memory enhancement and antiaging in Sagamu, Nigeria. Eur J Med Plants 2(3):262–275CrossRefGoogle Scholar
  22. Enabulele O, Enabulele JE (2016) Nigeria's national health act: an assessment of health professionals' knowledge and perception. Niger Med J 57(5):260–265CrossRefPubMedPubMedCentralGoogle Scholar
  23. Esan O, Abdumalik J, Eaton J, Kola L, Fadahunsi W, Gureje O (2014) Global mental health reforms: mental health Care in Anglophone West Africa. Psychiatr Serv 65(9):1084–1087CrossRefPubMedGoogle Scholar
  24. Federal Ministry of Health (2011) Nigeria pharmaceutical country profile. Pp 12 Available from http://nairametrics.com/wp-content/.../Nigeria_Pharma-Sector-Profile_032011_Ebook.pdf
  25. Federal Ministry of Health (2016). Speciality hospitals under the federal government. Available from http://www.health.gov.ng/index.php/parastatals/specialty-hospitals
  26. Gao S, Ogunniyi A, Hall KS, Baiyewu O, Unverzagt FW, Lane KA, Murrell JR, Gureje O, Hake AM, Hendrie HC (2016) Dementia incidence declined in African-Americans but not in Yoruba. Alzheimer's Dement J Alzheimer's Assoc 12(3):244–251CrossRefGoogle Scholar
  27. Hall K, Murrell J, Ogunniyi A, Deeg M, Baiyewu O, Gao S, Gureje O, Dickens J, Evans R, Smith Gamble V, Unverzagt FW, Shen J, Hendrie H (2006) Cholesterol, APOE genotype, and Alzheimer disease: an epidemiologic study of Nigerian Yoruba. Neurology 66(2):223–227CrossRefPubMedPubMedCentralGoogle Scholar
  28. Hendrie HC, Osuntokun BO, Hall KS, Ogunniyi AO, Hui SL, Unverzagt FW, Gureje O, Rodenberg CA, Baiyewu O, Musick BS (1995) Prevalence of Alzheimer's disease and dementia in two communities: Nigerian Africans and African Americans. Am J Psychiatr 152(10):1485–1492CrossRefPubMedGoogle Scholar
  29. IBRO (2015). IBRO Newsletter December 2015. Available from http://ibro.info/news/ibro-newsletter-december-2015/
  30. ICiR (2016). INVESTIGATION: How drug addiction threatens a generation of Northern Nigerian women (Part 1). Available from http://www.premiumtimesng.com/news/headlines/215905-investigation-drug-addiction-threatens-generation-northern-nigerian-women-part-1.html
  31. Iheanacho T, Kapadia D, Ezeanolue CO, Osuji AA, Ogidi AG, Ike A, Patel D, Stefanovics E, Rosenheck R, Obiefune M, Ezeanolue EE (2016) Attitudes and beliefs about mental illness among church-based lay health workers: experience from a prevention of mother-to-child HIV transmission trial in Nigeria. Int J Culture Ment Health 9(1):1–13CrossRefGoogle Scholar
  32. Imam I, Akinyemi R (2016) Nigeria. Pract Neurol 16:75–77CrossRefPubMedGoogle Scholar
  33. Ishola IO, Adamson FM, Adeyemi OO (2017) Ameliorative effect of kolaviron, a biflavonoid complex from Garcinia Kola seeds against scopolamine-induced memory impairment in rats: role of antioxidant defense system. Metab Brain Dis 32(1):235–245CrossRefPubMedGoogle Scholar
  34. Juliano SL (2012) Report on the African teaching tools workshops. Neurology 78:1797–1799CrossRefPubMedGoogle Scholar
  35. Karikari TK, Cobham AE, Ndams IS (2016) Building sustainable neuroscience capacity in Africa: the role of non-profit organisations. Metab Brain Dis 31(1):3–9CrossRefPubMedGoogle Scholar
  36. KBNF (2015) Korle Bu neuroscience foundation: projects. Available from http://kbnf.org/current-projects/
  37. Lambo TA (1956) Neuropsychiatric observations in the western region of Nigeria. Br Med J 2(5006):1388–1394CrossRefPubMedPubMedCentralGoogle Scholar
  38. Lambo TA (1960) Further neuropsychiatric observations in Nigeria. Br Med J 2(5214):1696–1704CrossRefPubMedPubMedCentralGoogle Scholar
  39. Lester D, Akande A (1994) Attitudes about suicide among the Yoruba of Nigeria. J Soc Psychol 134(6):851–853CrossRefPubMedGoogle Scholar
  40. Liz J (2011) Building neuroscience capacity in. Africa Available from https://www.dal.ca/news/2011/11/28/building-neuroscience-capacity-in-africa.html
  41. Makanjuola RO (1985) Recurrent unipolar manic disorder in the Yoruba Nigerian: further evidence. Br J Psychiatry 147(4):434–437CrossRefPubMedGoogle Scholar
  42. McClelland SIII, Harris KS (2007) Legacies of E. LATUNDE ODEKU: the first African-American neurosurgeon trained in the United States. Neurosurgery 60(4):769–772CrossRefPubMedGoogle Scholar
  43. Mussein I (1981) Islamic medicine and its influence on traditional Hausa practitioners in northern Nigeria. University of Wisconsin-Madison, USA, p 251Google Scholar
  44. Neal RV (1998) Merchants of death target Africa: countries used as springboards for international drug trafficking. Africa Recovery 12(1):7Google Scholar
  45. Nuhu FT, Fawole JO, Babalola OJ, Ayilara OO, Sulaiman ZT (2010) Social consequences of epilepsy: a study of 231 Nigerian patients. Ann Afr Med 9(3):170–175CrossRefPubMedGoogle Scholar
  46. Nuhu FT, Lasisi MD, Yusuf AJ, Aremu SB (2013) Suicide risk among adults with epilepsy in Kaduna, Nigeria. Gen Hosp Psychiatry 35(5):517CrossRefPubMedGoogle Scholar
  47. Obiako OR, Sheikh TL, Kehinde JA, Iwuozo EU, Ekele N, Elonu CC, Amaechi AU, Hayatudeen N (2014) Factors affecting epilepsy treatment outcomes in Nigeria. Acta Neurol Scand 130(6):360–367CrossRefPubMedGoogle Scholar
  48. Obiako OR, Sheikh TL, Kehinde JA, Iwuozo EU, Ekele N, Okungbowa CE, Kalu AO, Muhammed A, Adebayo F, Aniweta CI (2015) Aetiology and precipitants of epileptic seizures among Nigerians treated at two tertiary hospitals in Kaduna state, Northern Nigeria. West Afr J Med 34(1):37–43PubMedGoogle Scholar
  49. Ogundele OM, Ajonijebu DC, Adeniyi PA, Alade OI, Balogun WG, Cobham AE, Ishola AO, Amin A (2014) Cerebrovascular changes in the rat brain in two models of ischemia. Pathophysiology 21(3):199–209CrossRefPubMedGoogle Scholar
  50. Ojagbemi AA, Akinyemi RO, Baiyewu O (2013) Neuropsychiatric symptoms in Nigerian patients with Parkinson's disease. Acta Neurol Scand 128(1):9–16CrossRefPubMedGoogle Scholar
  51. Ojo J (2016). The non-implementation of Nigeria’s national health act. Available from http://punchng.com/non-implementation-nigerias-national-health-act/
  52. Okpataku CI, Kwanashie HO, Ejiofor JI, Olisah VO (2014) Prevalence and socio-demographic risk factors associated with psychoactive substance use in psychiatric out-patients of a tertiary hospital in Nigeria. Niger Med J 55(6):460–464CrossRefPubMedPubMedCentralGoogle Scholar
  53. Okubadejo N, Britton A, Crews C, Akinyemi R, Hardy J, Singleton A, Bras J (2008) Analysis of Nigerians with apparently sporadic Parkinson disease for mutations in LRRK2, PRKN and ATXN3. PLoS One 3(10):e3421CrossRefPubMedPubMedCentralGoogle Scholar
  54. Olajide OJ, Enaibe BU, Bankole OO, Akinola OB, Laoye BJ, Ogundele OM (2016) Kolaviron was protective against sodium azide (NaN3) induced oxidative stress in the prefrontal cortex. Metab Brain Dis 31(1):25–35CrossRefPubMedGoogle Scholar
  55. Olatunji PB, Fasola RT, Onasanwo SA (2016) Ethnobotanical survey of plants used as memory enhancer in three states of southwestern Nigeria. J Appl Pharm Sci 6(09):209–214Google Scholar
  56. Oluwole LO, Obadeji A, Dada UM (2015) Burden of stigma among relatives of Nigerian patients living with epilepsy. J Health Res Rev 2(2):61–65CrossRefGoogle Scholar
  57. Omigbodun O, Dogra N, Esan O, Adedokun B (2008) Prevalence and correlates of suicidal behaviour among adolescents in Southwest Nigeria. Int J Soc Psychiatry 54(1):34–46CrossRefPubMedGoogle Scholar
  58. Onwuekwe IO, Ezeala-Adikaibe B (2011) Prevalence and distribution of neurological disease in a neurology Clinic in Enugu, Nigeria. Ann Med Health Sci Res 1(1):63–67PubMedPubMedCentralGoogle Scholar
  59. Onwuekwe IO, Ekenze OS, Bzeala-Adikaibe OS, Ejekwu JU (2012) Depression in patients with epilepsy: a study from Enugu, South East Nigeria. Ann Med Health Sci Res 2(1):10–13CrossRefPubMedPubMedCentralGoogle Scholar
  60. Osuntokun BO (1968) An ataxic neuropathy in Nigeria. A clinical, biochemical and electrophysiological study. Brain 91(2):215–248CrossRefPubMedGoogle Scholar
  61. Osuntokun BO, Monekosso GL, Wilson J (1969) Relationship of a degenerative tropical neuropathy to diet: report of a field survey. Br Med J 1(5643):547–550CrossRefPubMedPubMedCentralGoogle Scholar
  62. Owoyele BV, Wuraola CO, Soladoye AO, Olaleye SB (2004) Studies on the anti-inflammatory and analgesic properties of Tithonia diversifolia leaf extract. J Ethnopharmacol 90(2):317–321CrossRefPubMedGoogle Scholar
  63. Owoyele BV, Adebukola OM, Funmilayo AA, Soladoye AO (2008) Anti-inflammatory activities of ethanolic extract of Carica papaya leaves. Inflammopharmacology 16(4):168–173CrossRefPubMedGoogle Scholar
  64. Oyebode F (2004) Obituary: Thomas Adeoye Lambo O.B.E. Psychiatr Bull 28(12):469CrossRefGoogle Scholar
  65. Pela OA, Ebie JC (1982) Drug abuse in Nigeria: a review of epidemiological studies. Bull Narc 34(3–4):91–99PubMedGoogle Scholar
  66. Quansah E, Karikari TK (2015) Motor neuron diseases in sub-Saharan Africa: the need for more population-based studies. Biomed Res Int 298409:1–9CrossRefGoogle Scholar
  67. Quirk GJ (1999) Neuroscience in developing countries: getting around the problems. Int J Neurosci 99(1–4):89–103CrossRefPubMedGoogle Scholar
  68. Román GC (1992) Neuroepidemiology around the world: various countries. Neuroepidemiology 11:111–112CrossRefGoogle Scholar
  69. Ross C (2010). Novartis doubles plan for Cambridge. Available from http://archive.boston.com/business/healthcare/articles/2010/10/27/novartis_doubles_plan_for_cambridge/
  70. Sanni AA, Adebayo FO (2013) Nigeria mental health act, 2013 assessment: a policy towards modern international standards. Am Acad Scholarly Res J 6:1–13Google Scholar
  71. Sanya EO, Ayodele OE, Olanrewaju TO (2010) Interest in neurology during medical clerkship in three Nigerian medical schools. BMC Med Educ 10:36CrossRefPubMedPubMedCentralGoogle Scholar
  72. SCImago (2017). SJR — SCImago journal & country rank. Available from http://www.scimagojr.com
  73. Senkubuge F, Mayosi BM (2013) The state of the national health research system in South Africa. In: Padarath A, English R (eds) South African health review 2012/13, health systems trust, Durban, pp 141–150Google Scholar
  74. SONA (1997). Society of Neuroscientists of Africa Newsletter 1(2)Google Scholar
  75. Steel Z, Chey T, Silove D, Marnane C, Bryant RA, van Ommeren M (2009) Association of torture and other potentially traumatic events with mental health outcomes among populations exposed to mass conflict and displacement: a systematic review and meta-analysis. JAMA 302(5):537–549CrossRefPubMedGoogle Scholar
  76. Tabiowo E (2016). Senate uncovers N273bn ‘fraud’ at TETFund. Available from http://www.blueprint.ng/senate-uncovers-n273bn-fraud-at-tetfund/
  77. Taiwo H, Ladapo O, Aina OF, Lawal RA, Adebiyi OP, Olomu SO, Aina RB (2008) Long stay patients in a psychiatric hospital in Lagos, Nigeria. Afr J Psychiatry 11:128–132CrossRefGoogle Scholar
  78. Thompson RF, Donegan NH (1987) Learning and memory. In: Adelman G (ed) Encyclopedia of neuroscience, Boston: Birkhauser, vol 1, pp 571–574Google Scholar
  79. Thomsen LB, Burkhart, Moos T (2015) A triple culture model of the blood-brain barrier using porcine brain endothelial cells, astrocytes and Pericytes. PLoS ONE 10(8):e0134765CrossRefPubMedPubMedCentralGoogle Scholar
  80. Ude PU (2015) Policy analysis on Nigerian lunacy act (1958): the need for a new legislation. J Psychiatry 19:1–6Google Scholar
  81. UN-DESA (2015). World population prospects: the 2015 revision. United Nations Department of economic and social affairs. Available from https://esa.un.org/unpd/wpp/
  82. Wahab KW, Ugheoke AJ (2009) Migraine: prevalence and associated disability among Nigerian undergraduates. Can J Neurol Sci/Journal Canadien des Sciences Neurologiques 36(2):216–221CrossRefPubMedGoogle Scholar
  83. WHO (2001) Mental health: new understanding new hope. World health report. Available from www.who.int/whr/2001/en/whr01_en.pdf?ua=1 Google Scholar
  84. WHO (2015). Suicide rates data by country. Available from http://apps.who.int/gho/data/node.main.MHSUICIDE?lang=en
  85. WHO-AIMS (2006). Mental Health System in Nigeria. Available from http://www.who.int/mental_health/evidence/WHO-AIMS/en/index.html
  86. Yusuf S, Baden T, Prieto-Godino LL (2014) Bridging the gap: establishing the necessary infrastructure and knowledge for teaching and research in neuroscience in Africa. Metab Brain Dis 29(2):217–220CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • Wasiu Gbolahan Balogun
    • 1
  • Ansa Emmanuel Cobham
    • 2
    • 3
  • Abdulbasit Amin
    • 4
    • 5
  1. 1.Advanced Medical and Dental InstituteUniversiti Sains MalaysiaBertamMalaysia
  2. 2.School of Biological SciencesMonash UniversityMelbourneAustralia
  3. 3.Department of Anatomy, Faculty of Basic Medical SciencesUniversity of CalabarCalabarNigeria
  4. 4.Instituto Gulbenkian de CiênciaOeirasPortugal
  5. 5.Department of Physiology, Faculty of Basic Medical SciencesUniversity of IlorinIlorinNigeria

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