Metabolic Brain Disease

, Volume 30, Issue 2, pp 497–506 | Cite as

Role of social factors on cell death, cerebral plasticity and recovery after stroke

Research Article


Stroke is a serious global health care problem. It is now is the fourth leading cause of death and the primary cause of adult disability in the United States. Substantial evidence from both experimental and clinical studies has demonstrated that social isolation (SI) can increase stroke incidence and impair recovery. Epidemiological studies demonstrate that an increasing number of patients are living alone, and as the aging population increases, loneliness will only increase in prevalence. SI is increasingly identified as an independent risk factor for all-cause mortality. In contrast, individuals with high levels of social support exhibit more rapid and extensive functional and cognitive recovery after a wide variety of pathological insults, including stroke. Clinical data suggests that SI is an important risk factor for increased mortality and delayed functional recovery following ischemic stroke. Attesting to the importance of mortality and behavioral factors in stroke outcome is that these same effects can be reproduced in animal models of experimental stroke. This has allowed researchers to identify several mechanistic changes that occur with affiliative interactions. These include decreased systemic inflammation, elaboration of growth factors including brain derived neurotropic factor (BDNF), enhanced neurogenesis, and improved neuroimmune responsiveness in group housed animals. These may mediate the beneficial effects of social interaction on improving stroke recovery and reducing neuronal death. In this review we provide an overview of the effects of SI on ischemic injury and recovery and discuss their clinical and therapeutic implications.


Social isolation Social interaction Brain plasticity Stroke Behavior 



This work was supported by National Institutes of Health grants R01 NSO77769 and NS055215 (to L.D.M.) and American Heart Association grant 11POST7430045 to V.R.V


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Venugopal Reddy Venna
    • 1
  • Louise D. McCullough
    • 1
    • 2
    • 3
  1. 1.Department of NeuroscienceUniversity of Connecticut Health CenterFarmingtonUSA
  2. 2.Department of NeurologyFarmingtonUSA
  3. 3.The Stroke Center at Hartford HospitalHartfordUSA

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