Abstract
Experimental cerebral ischemic stroke is exacerbated by inflammatory T-cells and is accompanied by systemic increases in CD4+CD25+Foxp3+ regulatory T-cells (Treg). To determine their effect on ischemic brain injury, Treg were depleted in Foxp3DTR mice prior to stroke induction. In contrast to a recent Nature Medicine report, our results demonstrate unequivocally that Treg depletion did not affect stroke infarct volume, thus failing to implicate this regulatory pathway in limiting stroke damage.
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Acknowledgments
The authors wish to thank Dr. Sushmita Sinha, Ms. Sandhya Subramanian and Dr. Suzan Dziennis for helpful discussions and Ms. Eva Niehaus and Heather Hoem for assistance in preparing the manuscript. This work was supported by NIH grant NR03521 and the Biomedical Laboratory R&D Service, Department of Veterans Affairs.
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The authors declare that they have no conflict of interest.
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Xuefang Ren and Kozaburo Akiyoshi contributed equally to this work.
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Ren, X., Akiyoshi, K., Vandenbark, A.A. et al. CD4+FoxP3+ regulatory T-cells in cerebral ischemic stroke. Metab Brain Dis 26, 87–90 (2011). https://doi.org/10.1007/s11011-010-9226-6
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DOI: https://doi.org/10.1007/s11011-010-9226-6