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Metabolic Brain Disease

, Volume 26, Issue 1, pp 87–90 | Cite as

CD4+FoxP3+ regulatory T-cells in cerebral ischemic stroke

  • Xuefang Ren
  • Kozaburo Akiyoshi
  • Arthur A. Vandenbark
  • Patricia D. Hurn
  • Halina Offner
Short Communication

Abstract

Experimental cerebral ischemic stroke is exacerbated by inflammatory T-cells and is accompanied by systemic increases in CD4+CD25+Foxp3+ regulatory T-cells (Treg). To determine their effect on ischemic brain injury, Treg were depleted in Foxp3DTR mice prior to stroke induction. In contrast to a recent Nature Medicine report, our results demonstrate unequivocally that Treg depletion did not affect stroke infarct volume, thus failing to implicate this regulatory pathway in limiting stroke damage.

Keywords

Cerebral ischemia T lymphocyte T regulatory cells Middle cerebral artery occlusion Stroke 

Notes

Acknowledgments

The authors wish to thank Dr. Sushmita Sinha, Ms. Sandhya Subramanian and Dr. Suzan Dziennis for helpful discussions and Ms. Eva Niehaus and Heather Hoem for assistance in preparing the manuscript. This work was supported by NIH grant NR03521 and the Biomedical Laboratory R&D Service, Department of Veterans Affairs.

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Xuefang Ren
    • 1
    • 2
  • Kozaburo Akiyoshi
    • 2
  • Arthur A. Vandenbark
    • 1
    • 3
    • 4
  • Patricia D. Hurn
    • 2
    • 3
  • Halina Offner
    • 1
    • 2
    • 3
  1. 1.Neuroimmunology Research, R&D-31Portland Veterans Affairs Medical CenterPortlandUSA
  2. 2.Department of Anesthesiology and Perioperative MedicineOregon Health & Science UniversityPortlandUSA
  3. 3.Department of NeurologyOregon Health & Science UniversityPortlandUSA
  4. 4.Department of Molecular Microbiology & ImmunologyOregon Health & Science UniversityPortlandUSA

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