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Molecular and Cellular Biochemistry

, Volume 404, Issue 1–2, pp 171–179 | Cite as

Overexpression of ADAMTS-7 leads to accelerated initiation and progression of collagen-induced arthritis in mice

  • Yuying Zhang
  • Fanhua Wei
  • Chuan-ju Liu
Article

Abstract

The aim of the present study is to determine whether ADAMTS-7 contributes to the onset and severity of joint inflammation in the pathogenesis of inflammatory arthritis. ADAMTS-7 was found to be elevated in the course of collagen-induced arthritis (CIA). ADAMTS-7 transgenic (TG) mice were more susceptible to the induction of CIA. The onset of CIA was accelerated and the arthritic severity was increased in TG mice compared to wild-type mice. The overall incidence was also significantly higher in TG mice. In addition, arthritic TG mice displayed significantly higher clinical and histological arthritis scores. The COMP degradative fragments were significantly elevated in articular cartilage and sera in CIA models of TG mice. Furthermore, the production of tumor necrosis factor-alpha and interleukin-17 was also increased in serum and draining lymph nodes of arthritic TG mice. Therefore, these data provided the in vivo evidence, suggesting that ADAMTS-7 may play an important role in the pathogenesis of inflammatory arthritis, and that inhibition of ADAMTS-7 may be a potential target to ameliorate the severity of inflammatory arthritis.

Keywords

ADAMTS-7 COMP Transgenic mice Collagen-induced arthritis TNF-α 

Notes

Acknowledgments

This work was supported partly by NIH research Grants R01AR062207, R01AR061484, R56AI100901, and a Disease Targeted Research Grant from Rheumatology Research Foundation (to C. J. Liu). The founding resources had no involvement in study design, in the collection and analysis of data.

Conflict of interest

The authors have no financial conflicts of interest.

References

  1. 1.
    Feldmann M, Brennan FM, Maini RN (1996) Rheumatoid arthritis. Cell 85:307–310CrossRefPubMedGoogle Scholar
  2. 2.
    Jones GC, Riley GP (2005) ADAMTS proteinases: a multi-domain, multi-functional family with roles in extracellular matrix turnover and arthritis. Arthritis Res Ther 7:160–169CrossRefPubMedCentralPubMedGoogle Scholar
  3. 3.
    Stanton H, Rogerson FM, East CJ, Golub SB, Lawlor KE et al (2005) ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro. Nature 434:648–652CrossRefPubMedGoogle Scholar
  4. 4.
    Glasson SS, Askew R, Sheppard B, Carito B, Blanchet T et al (2005) Deletion of active ADAMTS5 prevents cartilage degradation in a murine model ofosteoarthritis. Nature 434:644–648CrossRefPubMedGoogle Scholar
  5. 5.
    Liu CJ (2009) The role of ADAMTS-7 and ADAMTS-12 in the pathogenesis of arthritis. Nat Clin Pract Rheumatol 5:38–45CrossRefPubMedGoogle Scholar
  6. 6.
    Liu CJ, Kong W, Ilalov K, Yu S, Xu K et al (2006) ADAMTS-7: a metalloproteinase that directly binds to and degrades cartilage oligomeric matrix protein. FASEB J 20:988–990CrossRefPubMedCentralPubMedGoogle Scholar
  7. 7.
    Bai XH, Wang DW, Kong L, Zhang Y, Luan Y et al (2009) ADAMTS-7, a direct target of PTHrP, adversely regulates endochondral bone growth by associating with and inactivating GEP growth factor. Mol Cell Biol 29:4201–4219CrossRefPubMedCentralPubMedGoogle Scholar
  8. 8.
    Wang L, Zheng J, Bai X, Liu B, Liu CJ et al (2009) ADAMTS-7 mediates vascular smooth muscle cell migration and neointima formation in balloon-injured rat arteries. Circ Res 104:688–698CrossRefPubMedGoogle Scholar
  9. 9.
    Pu X, Xiao Q, Kiechl S, Chan K, Fg FL et al (2013) ADAMTS7 cleavage and vascular smooth muscle cell migration is affected by a coronary-artery-disease-associated variant. Am J Hum Genet 92:366–374CrossRefPubMedCentralPubMedGoogle Scholar
  10. 10.
    Lai Y, Bai X, Zhao Y, Tian Q, Liu B et al (2012) ADAMTS-7 forms a positive feedback loop with TNF-alpha in the pathogenesis of osteoarthritis. Ann Rheum Dis 73:1575–1584CrossRefGoogle Scholar
  11. 11.
    Pierer M, Wagner U, Rossol M, Ibrahim S (2011) Toll-like receptor 4 is involved in inflammatory and joint destructive pathways in collagen-induced arthritis in DBA1J mice. PLoS One 6:e23539CrossRefPubMedCentralPubMedGoogle Scholar
  12. 12.
    Blanchet MR, Gold M, Maltby S, Bennett J, Petri B et al (2010) Loss of CD34 leads to exacerbated autoimmune arthritis through increased vascularpermeability. J Immunol 184:1292–1299CrossRefPubMedGoogle Scholar
  13. 13.
    van der Sluijs JA, Geesink RG, van der Linden AJ, Bulstra SK, Kuyer B et al (1992) The reliability of the Mankin score for osteoarthritis. J Orthop Res 10:58–61CrossRefPubMedGoogle Scholar
  14. 14.
    Lai Y, Yu XP, Zhang Y, Tian Q, Song H et al (2012) Enhanced COMP catabolism detected in serum of patients with arthritis and animal disease models through a novel capture ELISA. Osteoarthr Cartil 20:854–862CrossRefPubMedCentralPubMedGoogle Scholar
  15. 15.
    Tsuzaka K, Itami Y, Takeuchi T, Shinozaki N, Morishita T et al (2010) ADAMTS5 is a biomarker for prediction of response to infliximab in patients with rheumatoid arthritis. J Rheumatol 37:1454–1460CrossRefPubMedGoogle Scholar
  16. 16.
    Misumi K, Vilim V, Hatazoe T, Murata T, Fujiki M et al (2002) Serum level of cartilage oligomeric matrix protein (COMP) in equine osteoarthritis. Equine Vet J 34:602–608CrossRefPubMedGoogle Scholar
  17. 17.
    Mansson B, Carey D, Alini M, Ionescu M, Rosenberg LC et al (1995) Cartilage and bone metabolism in rheumatoid arthritis. Differences between rapid and slow progression of disease identified by serum markers of cartilage metabolism. J Clin Invest 95:1071–1077CrossRefPubMedCentralPubMedGoogle Scholar
  18. 18.
    Petersson IF, Boegard T, Svensson B, Heinegard D, Saxne T (1998) Changes in cartilage and bone metabolism identified by serum markers in early osteoarthritis of the knee joint. Br J Rheumatol 37:46–50CrossRefPubMedGoogle Scholar
  19. 19.
    Yamada H, Yoneda M, Inaguma S, Watanabe D, Banno S et al (2013) Infliximab counteracts tumor necrosis factor-alpha-enhanced induction of matrix metalloproteinases that degrade claudin and occludin in non-pigmented ciliary epithelium. Biochem Pharmacol 85:1770–1782CrossRefPubMedGoogle Scholar
  20. 20.
    van den Berg WB, van Riel PL (2005) Uncoupling of inflammation and destruction in rheumatoid arthritis: myth or reality? Arthritis Rheum 52:995–999CrossRefPubMedGoogle Scholar
  21. 21.
    McInnes IB, Schett G (2007) Cytokines in the pathogenesis of rheumatoid arthritis. Nat Rev Immunol 7:429–442CrossRefPubMedGoogle Scholar
  22. 22.
    Feldmann M, Brennan FM, Maini RN (1996) Role of cytokines in rheumatoid arthritis. Annu Rev Immunol 14:397–440CrossRefPubMedGoogle Scholar
  23. 23.
    Keffer J, Probert L, Cazlaris H, Georgopoulos S, Kaslaaris E et al (1991) Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis. EMBO J 10:4025–4031PubMedCentralPubMedGoogle Scholar
  24. 24.
    Kumar S, Blake SM, Emery JG (2001) Intracellular signaling pathways as a target for the treatment of rheumatoid arthritis. Curr Opin Pharmacol 1:307–313CrossRefPubMedGoogle Scholar
  25. 25.
    van den Berg WB, Miossec P (2009) IL-17 as a future therapeutic target for rheumatoid arthritis. Nat Rev Rheumatol 5:549–553CrossRefPubMedGoogle Scholar
  26. 26.
    Firestein GS (2003) Evolving concepts of rheumatoid arthritis. Nature 423:356–361CrossRefPubMedGoogle Scholar
  27. 27.
    Notley CA, Inglis JJ, Alzabin S, MsCann FE, McNamee KE et al (2008) Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novelimmunoregulatory pathway for Th1 and Th17 cells. J Exp Med 205:2491–2497CrossRefPubMedCentralPubMedGoogle Scholar
  28. 28.
    Ziolkowska M, Koc A, Luszczykiewicz G, Ksiezopolska-Pietrzak K, Klimczak E et al (2000) High levels of IL-17 in rheumatoid arthritis patients: IL-15 triggers in vitro IL-17 production via cyclosporin A-sensitive mechanism. J Immunol 164:2832–2838CrossRefPubMedGoogle Scholar
  29. 29.
    Luan Y, Kong L, Howell DR, Ilalov K, Fajardo M et al (2008) Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin. Osteoarthr Cartil 16:1413–1420CrossRefPubMedCentralPubMedGoogle Scholar
  30. 30.
    Guo F, Lai Y, Tian Q, Lin EA, Kong L et al (2010) Granulin-epithelin precursor binds directly to ADAMTS-7 and ADAMTS-12 and inhibits their degradation of cartilage oligomeric matrix protein. Arthritis Rheum 62:2023–2036PubMedCentralPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of Orthopaedic SurgeryNew York University Medical CenterNew YorkUSA
  2. 2.College of Life SciencesShandong Normal UniversityJinanChina
  3. 3.Department of Cell BiologyNew York University School of MedicineNew YorkUSA

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