Molecular and Cellular Biochemistry

, Volume 389, Issue 1–2, pp 79–84 | Cite as

Polymorphisms in glutathione S-transferase are risk factors for perioperative acute myocardial infarction after cardiac surgery: a preliminary study

  • Viktória Kovacs
  • Balazs Gasz
  • Borbala Balatonyi
  • Luca Jaromi
  • Peter Kisfali
  • Balazs Borsiczky
  • Gabor Jancso
  • Nandor Marczin
  • Sandor Szabados
  • Bela Melegh
  • Alotti Nasri
  • Elisabeth Roth


In the present study we explored glutathione S-transferase (GST) polymorphisms in selected patients who experienced accelerated myocardial injury following open heart surgery and compared these to a control group of patients without postoperative complications. 758 Patients were enrolled from which 132 patients were selected to genotype analysis according to exclusion criteria. Patients were divided into the following groups: Group I: control patients (n = 78) without and Group II.: study patients (n = 54) with evidence of perioperative myocardial infarction. Genotyping for GSTP1 A (Ile105Ile/Ala113Ala), B (Ile105Val/Ala113Ala) and C (Ile105Val/Ala113Val) alleles was performed by using real-time-PCR. The heterozygous AC allele was nearly three times elevated (18.5 vs. 7.7 %) in the patients who suffered postoperative myocardial infarction compared to controls. Contrary, we found allele frequency of 14.1 % for homozygous BB allele in the control group whereas no such allele combination was present in the study group. These preliminary results may suggest the protective role for the B and C alleles during myocardial oxidative stress whereas the A allele may represent predisposing risk for cellular injury in patients undergoing cardiac surgery.


Cardiac surgery Perioperative acute myocardial infarction Gene polymorphism Glutathione S-transferase P1 



This work was supported by the Hungarian Science Research Fund OTKA K78434 and the TÁMOP 4.2.2./B-10/1-2010-0029. The study was approved by TUKEB (3727.316-3255/2010).


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Viktória Kovacs
    • 1
  • Balazs Gasz
    • 2
  • Borbala Balatonyi
    • 1
  • Luca Jaromi
    • 3
  • Peter Kisfali
    • 3
  • Balazs Borsiczky
    • 1
  • Gabor Jancso
    • 1
  • Nandor Marczin
    • 4
  • Sandor Szabados
    • 5
  • Bela Melegh
    • 3
  • Alotti Nasri
    • 2
  • Elisabeth Roth
    • 1
  1. 1.Department of Surgical Research and Techniques, Medical FacultyUniversity of PécsPecsHungary
  2. 2.Department of Cardiac SurgeryZala County HospitalZalaegerszegHungary
  3. 3.Department of Medical GeneticsUniversity of PécsPecsHungary
  4. 4.Faculty of Medicine, Imperial College of LondonLondonUK
  5. 5.Heart Institute, Medical Faculty, University of PécsPecsHungary

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