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miR-141 suppresses proliferation and motility of gastric cancer cells by targeting HDGF

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Abstract

miR-141 belongs to the miR-200 family, and has been found to be associated with numerous human malignancies; however, its role in gastric cancer (GC) has not been examined in detail. Here, we validated that miR-141 was decreased in GC tissues and cell lines. Forced expression of miR-141 significantly repressed GC cell proliferation and colony formation. Furthermore, miR-141 suppressed in vitro migration and invasion of GC cells. Hepatoma-derived growth factor (HDGF) was confirmed to be a direct target of miR-141 in GC cells. The suppressive effects of miR-141 on GC cell proliferation, colony formation, in vitro migration, and invasion were partially mediated by suppressing HDGF expression. Moreover, the expression of HDGF was negatively correlated with miR-141 in GC tissues. Our data suggest that miR-141 might be associated and plays essential role in GC progression.

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The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Gastroenterology, The No.1 People’s Hospital of Jingmen, Jingmen, 448000, China

    Bitao Chen, Hongxing Li & Shitao Xia

  2. Department of Urology, Wuhan No,1 Hospital, Huazhong University of Science and Technology, Wuhan, 430033, China

    Tao Huang & Lei Lv

  3. Department of Oncology, The Central Hospital of Wuhan, Wuhan, 430014, China

    Jun Jiang

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  1. Bitao Chen
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  2. Tao Huang
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  3. Jun Jiang
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  5. Hongxing Li
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Correspondence to Tao Huang.

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Chen, B., Huang, T., Jiang, J. et al. miR-141 suppresses proliferation and motility of gastric cancer cells by targeting HDGF. Mol Cell Biochem 388, 211–218 (2014). https://doi.org/10.1007/s11010-013-1912-3

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  • DOI: https://doi.org/10.1007/s11010-013-1912-3

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