Molecular and Cellular Biochemistry

, Volume 361, Issue 1–2, pp 67–70 | Cite as

The potential role of RTN3 in monocyte recruitment and atherosclerosis



The recruitment of monocytes to arterial wall and their transformation into macrophages are generally accepted as important early events in the pathogenesis of atherosclerosis (AS). Our research group found Reticulon3 (RTN3), a member of the reticulon family, may be a candidate pathogenic element in the progress of AS. But it is virtually unknown in which process RTN3 may participate in and regulate the pathogenesis of AS. Here, we hypothesis that RTN3 may participate in the continuous process of circulating monocyte recruitment in AS including: (1) monocyte spreading and adhesion to luminal endothelium; (2) transendothelial migration and may also contribute to the conversion of monocyte to macrophage in subendothelium.


Adhesion molecules Transmigration Differentiation Reticulons Coronary artery disease 



This research was supported by National Nature Sciences foundation of China (30900624), Doctoral Fund of Ministry of Education of China (200805331005), and Hunan Provincial Innovation Foundation for Postgraduate (CX2010B093).


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Copyright information

© Springer Science+Business Media, LLC. 2011

Authors and Affiliations

  1. 1.Department of CardiologyThe Second Xiangya Hospital of Central South UniversityChangsha, HunanPeople’s Republic of China
  2. 2.Department of Cell BiologySchool of Biological Science and Technology, Central South UniversityChangsha, HunanPeople’s Republic of China

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