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Alterations in serum selenium levels and their relation to troponin I in acute myocardial infarction

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Abstract

Selenium (Se) is an essential trace element with antioxidant function. The aim of the present study was to estimate the alterations of Se serum level during the acute phase of myocardial infarction and its relation to biomarkers of myocardial necrosis. Serum Se levels were measured at admission and after 24 h in 60 consecutive patients with acute coronary syndrome (both with and without ST elevation). Troponin I (TnI) was assessed at admission and then twice daily for 3 days; patients with normal levels were excluded. Fifty-five patients with acute MI (positive TnI) were included into the analysis. During the first day of hospitalization, patients received standard therapy, including acetylsalicylic acid, clopidogrel, and heparin or enoxaparin; all underwent urgent coronary angiography and percutaneous intervention, when appropriate. Mean Se levels at baseline and 24 h later were comparable (67.1 ± 2.1 vs. 67.2 ± 1.8 μg/L, ns). Linear regression has shown significant correlation between baseline Se levels and peak TnI (y = 3.4x − 116, r 2 = 0.13, P = 0.008). Positive correlation was found also between the peak TnI and the difference from baseline to 24 h (y = 2.2x + 115, r 2 = 0.08, P = 0.04). Moreover, close negative correlation was observed between baseline Se levels and the difference from baseline to 24 h (y = −0.9x + 62.7, r 2 = 0.55, P<0.001). Our results have shown marked individual changes in Se levels during the acute phase of MI as well as correlation between Se levels and peak TnI. These results suggest that alterations in serum Se may be related to the extent of myocardial infarction.

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Acknowledgment

This study was supported by the grant of the Czech Ministry of Health, Nr. 00000064203.

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Authors and Affiliations

  1. Department of Cardiology, Cardiovascular Center, Na Homolce Hospital, Prague, Czech Republic

    Barbara Kutil, Andreas Krüger & Dagmar Vondrakova

  2. Charite – Universitätsmedizin, Berlin, Germany

    Barbara Kutil

  3. Department of Cardiology, Cardiovascular Center, Na Homolce Hospital, Roentgenova 2, 15030, Prague, Czech Republic

    Petr Ostadal

  4. Department of Cardiology, Cardiovascular Center, University Hospital Motol, Prague, Czech Republic

    Jiri Vejvoda & David Alan

  5. Department of Clinical Biochemistry and Pathobiochemistry, University Hospital Motol, Prague, Czech Republic

    Jiri Kukacka & Jana Cepova

Authors
  1. Barbara Kutil
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  2. Petr Ostadal
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  3. Jiri Vejvoda
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  4. Jiri Kukacka
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  5. Jana Cepova
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  6. David Alan
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  7. Andreas Krüger
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  8. Dagmar Vondrakova
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Correspondence to Petr Ostadal.

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Kutil, B., Ostadal, P., Vejvoda, J. et al. Alterations in serum selenium levels and their relation to troponin I in acute myocardial infarction. Mol Cell Biochem 345, 23–27 (2010). https://doi.org/10.1007/s11010-010-0555-x

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  • DOI: https://doi.org/10.1007/s11010-010-0555-x

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