Molecular and Cellular Biochemistry

, Volume 334, Issue 1–2, pp 99–103 | Cite as

A new Rac/PAK/GC/cGMP signaling pathway

  • Dagang Guo
  • J. Jillian Zhang
  • Xin-Yun Huang


Guanosine 3′,5′-cyclic monophosphate (cGMP) and small GTPase Rac are critical regulators of cell functions. Recently, Rac has been shown to use its downstream effector p21-activated kinase (PAK) to directly activate transmembrane guanylyl cyclases (GCs). This novel Rac/PAK/GC/cGMP signaling pathway bridges Rac and cGMP, and provides a general molecular mechanism for diverse receptors to regulate physiological functions such as cell migration through elevating the cellular cGMP level.


Guanylyl cyclase Rac PAK cGMP 



Research projects on guanylyl cyclases in our laboratory were supported by a grant from the NIH (GM84191).


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Copyright information

© Springer Science+Business Media, LLC. 2009

Authors and Affiliations

  1. 1.Department of PhysiologyCornell University Weill Medical CollegeNew YorkUSA

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