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Effects of administration of Embelin and Curcumin on lipid peroxidation, hepatic glutathione antioxidant defense and hematopoietic system during N-nitrosodiethylamine/Phenobarbital-induced hepatocarcinogenesis in Wistar rats

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Abstract

The effects of administration of Embelin (EMB) and Curcumin (CUR) on lipid peroxidation, hepatic glutathione antioxidant defense and hematopoietic cells were examined during N-nitrosodiethylamine (DENA-200 mg kg−1body wt, single I.P injection) initiated and Phenobarbital (PB-0.05% in drinking water orally for 13 weeks) promoted hepatocarcinogenesis in Wistar strain male albino rats. DENA/PB-induced hepatic damage was manifested by a significant drop in the hepatic glutathione antioxidant defense, increased lipid peroxidation and histological alterations like dysplasia, and atypical cells with abnormal chromatin pattern. Treatment with Curcumin (100 mg kg−1body wt) and Embelin (50 mg kg−1body wt) prevented the drop in hepatic glutathione antioxidant defense, decreased lipid peroxidation, minimized the histological alterations induced by DENA/PB, but showed toxic effects on the hematopoietic cells. Results indicate the beneficial effects of Embelin and Curcumin against oxidative tissue damage during chemically-induced hepatocarinogenesis in rats.

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Authors and Affiliations

  1. Department of Microbiology and Biotechnology, Bangalore University, Jnana Bharati Campus, Bangalore, 560 056, Karnataka, India

    Meenakshisundaram Sreepriya & Geetha Bali

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  1. Meenakshisundaram Sreepriya
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  2. Geetha Bali
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Correspondence to Meenakshisundaram Sreepriya.

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Sreepriya, M., Bali, G. Effects of administration of Embelin and Curcumin on lipid peroxidation, hepatic glutathione antioxidant defense and hematopoietic system during N-nitrosodiethylamine/Phenobarbital-induced hepatocarcinogenesis in Wistar rats. Mol Cell Biochem 284, 49–55 (2006). https://doi.org/10.1007/s11010-005-9012-7

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  • DOI: https://doi.org/10.1007/s11010-005-9012-7

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