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Molecular and Cellular Biochemistry

, Volume 280, Issue 1–2, pp 159–163 | Cite as

Subchronic exposure to high-dose ACE-inhibitor moexipril induces catalase activity in rat liver

  • E. Adeghate
  • M. Y. Hasan
  • A. S. Ponery
  • S. M. Nurulain
  • G. A. Petroianu
Article

Abstract

The long-term clinical effects of ACE-inhibitors have similarities with those of both fibrates and glitazones, activators of peroxisome proliferator activator receptor (PPAR) alpha and gamma, respectively. The antioxidant enzyme catalase, a heme protein that degrades hydrogen peroxide, is found at high concentrations in peroxisomes. Catalase activity is one of the recognized surrogate markers indicative of PPAR activation in the rat liver. The purpose of the study was to establish the effect of moexipril on catalase activity and to compare it with the effect of both saline controls and that of the known PPAR agonist clofibrate (positive control). Three groups of seven rats were used. All substances were applied i.p. daily for 5 days, followed by a 2-day break. The cycle was repeated eight times. After the final cycle (day 56) the animals were sacrificed and liver tissue collected. The number of catalase positive cells in both moexipril group (95% CI 57–61) and clofibrate group (95% CI 72–80) is higher than in controls (95% CI 3–16) (p ≤ 0.01). The number of catalase positive cells in the clofibrate group is higher than in the moexipril group (p ≤ 0.01). High-dose subchronic exposure to the ACE-inhibitor moexipril induces catalase activity in the rat liver to an extent comparable to fibrates. We suggest that some of the long-term advantages of ACE inhibitor use – beyond mere BP lowering – might be due to a PPAR mediated effect. (Mol Cell Biochem xxx: 159–163, 2005)

Keyword

ACE inhibitor catalase fibrates moexipril PPAR rodents 

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Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  • E. Adeghate
    • 2
  • M. Y. Hasan
    • 1
  • A. S. Ponery
    • 2
  • S. M. Nurulain
    • 1
  • G. A. Petroianu
    • 1
    • 3
  1. 1.Department of Pharmacology and TherapeuticsUAE University, Faculty of Medicine and Health SciencesAl AinUAE
  2. 2.Department of AnatomyUAE University, Faculty of Medicine and Health SciencesAl AinUAE
  3. 3.Department of Pharmacology and TherapeuticsUnited Arab Emirates UniversityAl AinUnited Arab Emirates

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