Molecular and Cellular Biochemistry

, Volume 269, Issue 1, pp 131–136 | Cite as

Effect of Tridax procumbens on liver antioxidant defense system during lipopolysaccharide-induced hepatitis in D-galactosamine sensitised rats

  • Vilwanathan Ravikumar
  • Kanchi Subramanian Shivashangari
  • Thiruvengadam Devaki


The present study was carried out to assess the effect of chloroform insoluble fraction of ethanolic extract of Tridax procumbens (TP) against D-Galactosamine/Lipopolysaccharide (D-GalN/LPS)-induced hepatitis in rats. Induction of rats with D-GalN/LPS (300 mg/kg body weight/30 μg/kg body weight) led to a marked increase in lipid peroxidation as measured by thiobarbituric acid reactive substances (TBARS) in liver. Further there was a decline in the activities of enzymic antioxidants such as superoxide dismutase, catalase, glutathione peroxidase, glutathione s-transferase and the levels of non-enzymic antioxidants namely reduced glutathione, vitamin C and vitamin E. These biochemical alterations were normalised upon pretreatment with TP extract. Thus, the above results suggest that TP (300 mg/kg body weight orally for 10 days) is very effective in allievating the D-GalN/LPS-induced oxidative stress suggesting its antioxidant property. (Mol Cell Biochem 269: 131–136, 2005)


antioxidants D-Galactosamine hepatitis lipid peroxidation lipopolysaccharide Tridax procumbens 


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Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  • Vilwanathan Ravikumar
    • 1
  • Kanchi Subramanian Shivashangari
    • 1
  • Thiruvengadam Devaki
    • 1
  1. 1.Department of BiochemistryUniversity of MadrasChennaiIndia

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