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Effect of Tridax procumbens on liver antioxidant defense system during lipopolysaccharide-induced hepatitis in D-galactosamine sensitised rats

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Abstract

The present study was carried out to assess the effect of chloroform insoluble fraction of ethanolic extract of Tridax procumbens (TP) against D-Galactosamine/Lipopolysaccharide (D-GalN/LPS)-induced hepatitis in rats. Induction of rats with D-GalN/LPS (300 mg/kg body weight/30 μg/kg body weight) led to a marked increase in lipid peroxidation as measured by thiobarbituric acid reactive substances (TBARS) in liver. Further there was a decline in the activities of enzymic antioxidants such as superoxide dismutase, catalase, glutathione peroxidase, glutathione s-transferase and the levels of non-enzymic antioxidants namely reduced glutathione, vitamin C and vitamin E. These biochemical alterations were normalised upon pretreatment with TP extract. Thus, the above results suggest that TP (300 mg/kg body weight orally for 10 days) is very effective in allievating the D-GalN/LPS-induced oxidative stress suggesting its antioxidant property. (Mol Cell Biochem 269: 131–136, 2005)

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  1. Department of Biochemistry, University of Madras, Guindy Campus, Chennai, India

    Vilwanathan Ravikumar, Kanchi Subramanian Shivashangari & Thiruvengadam Devaki

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  1. Vilwanathan Ravikumar
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  2. Kanchi Subramanian Shivashangari
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Correspondence to Thiruvengadam Devaki.

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Ravikumar, V., Shivashangari, K.S. & Devaki, T. Effect of Tridax procumbens on liver antioxidant defense system during lipopolysaccharide-induced hepatitis in D-galactosamine sensitised rats. Mol Cell Biochem 269, 131–136 (2005). https://doi.org/10.1007/s11010-005-3443-z

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