Anticancer drugs (Doxorubicin, Methotrexate, Daunorubicin, etc.,) shows excellent activity on killing cancer cells, equal amount of cytotoxicity is also observed in healthy cells as well due to its non-specificity. Modern drug delivery systems proved that the stimuli sensitive peptide-drug conjugate as an alternate method to overcome this problem of severe side effects caused by the anticancer agents. Therefore, our research group designed a novel hypothesize that, a combination of pH and thermo sensitive peptide-drug conjugate, a prodrug concept could be the lead method for the treatment of modern chemotherapy to solid tumors. This dual-sensitive peptide-drug conjugate combination strategy will develop a pioneer drug carrier in the field of drug delivery systems (DDS).
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We would like to thank the Department of Biotechnology, Government of India for financial support (Project Approval No: BT/PR16289/NER/95/113/2015).
Department of Biotechnology, Government of India (Project Approval No: BT/PR16289/NER/95/113/2015).
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Santhosh, S.B., Chandrasekar, M.J.N. Isoelectric Point Based Dual Sensitive Peptide-Drug Conjugate Prodrug to Target Solid Tumors. Int J Pept Res Ther 26, 2225–2229 (2020). https://doi.org/10.1007/s10989-020-10022-w
- Anticancer drug
- Peptide-drug conjugate