Isoelectric Point Based Dual Sensitive Peptide-Drug Conjugate Prodrug to Target Solid Tumors

Abstract

Anticancer drugs (Doxorubicin, Methotrexate, Daunorubicin, etc.,) shows excellent activity on killing cancer cells, equal amount of cytotoxicity is also observed in healthy cells as well due to its non-specificity. Modern drug delivery systems proved that the stimuli sensitive peptide-drug conjugate as an alternate method to overcome this problem of severe side effects caused by the anticancer agents. Therefore, our research group designed a novel hypothesize that, a combination of pH and thermo sensitive peptide-drug conjugate, a prodrug concept could be the lead method for the treatment of modern chemotherapy to solid tumors. This dual-sensitive peptide-drug conjugate combination strategy will develop a pioneer drug carrier in the field of drug delivery systems (DDS).

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Acknowledgements

We would like to thank the Department of Biotechnology, Government of India for financial support (Project Approval No: BT/PR16289/NER/95/113/2015).

Funding

Department of Biotechnology, Government of India (Project Approval No: BT/PR16289/NER/95/113/2015).

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Dr. MJNC and Mr. SBS conceptualised and developed the idea of the proposed work. SBS along with Dr. MJNC collected the data for the work. Both the authors were involved in the interpretation of the data and in critical revision of the manuscript preparation. The final approval and accountability rests with Dr. MJNC.

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Correspondence to M. J. N. Chandrasekar.

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Santhosh, S.B., Chandrasekar, M.J.N. Isoelectric Point Based Dual Sensitive Peptide-Drug Conjugate Prodrug to Target Solid Tumors. Int J Pept Res Ther 26, 2225–2229 (2020). https://doi.org/10.1007/s10989-020-10022-w

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Keywords

  • Anticancer drug
  • Peptide
  • Peptide-drug conjugate
  • Dual-sensitive
  • Prodrug