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Synthesis and Characterization of a Selective Alpha(v)Beta(3) Receptor Cyclic Peptide Antagonist Functionalized with a Chelating Group for Metal Labelling

  • Luca Monfregola
  • Michele Saviano
  • Stefania De Luca
Article

Abstract

Small radiolabelled compounds such as peptides are very attractive tools for the diagnosis of several different pathologies (Heppeler in Curr Med Chem 7:971–994, 2000). Among the possible biological targets for radiolabelled compounds, the alpha(v)beta(3) (αvβ3) integrin cell adhesion receptor has been extensively studied. It is expressed on proliferating but not quiescent endothelial cells and has been shown to be involved in tumour progression, angiogenesis and metastasis. The novel radioactive probe 111In-DTPA-RGDechi has been successfully employed for selective αvβ3 single-photon imaging studies. Herein we report the efficient synthetic protocol developed in order to obtain the conjugate diethylentriaminopentacetic acid (DTPA)-RGDechi in good yield and high purity.

Keywords

Solid phase synthesis Selective radioactive probe αvβ3 Receptor 

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Luca Monfregola
    • 1
  • Michele Saviano
    • 1
  • Stefania De Luca
    • 1
  1. 1.Istituto di Biostrutture e Bioimmagini IBB-CNRNaplesItaly

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