Bradykinin (Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg; BK) occupies a special place in the history of the development of solid-phase peptide synthesis (SPPS). It was the first biologically-active peptide to be synthesized by Merrifield using the new method. Since that time many hundreds of BK analogs have been synthesized by SPPS. Certain of these analogs show potential as drug candidates.
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Chan D. C., Gera L., Helfrich B., Helm K., Stewart J., Whalley E., Bunn P. (1996) Novel bradykinin antagonist dimer for the treatment of human lung cancers. Immunopharmacol 33, 201–204
Merrifield R. B. (1963) Solid Phase Peptide Synthesis. Synthesis of a tetrapeptide. J. Am. Chem. Soc. 85, 2149–2154
Merrifield R. B. (1964) Solid phase synthesis of bradykinin. Biochemistry 3, 1385–1390
Merrifield R. B., Stewart J. M. (1965) Automated peptide synthesis. Nature 207, 522–523
Merrifield R. B., Stewart J. M., Jernberg N. (1966) Instrument for automated synthesis of peptides. Anal. Chem. 38, 1905–1914
Schachter M., Uchida Y., Longridge D. J., Labedz T., Whalley E. T., Vavrek R. J., Stewart J. M. (1987) New synthetic antagonists of bradykinin. Brit. J. Pharmacol. 92, 851–855
Stewart J. M., Gera L. (1996) A new class of bradykinin antagonists containing indanylglycine. Immunopharmacol. 33, 174–177
Vavrek R. J., Stewart J. M. (1985) Competitive antagonists of bradykinin. Peptides 6, 161–164
Woolley D. W., Stewart J. M. (1964) Threonine analogs of bradykinin designed as antimetabolites. Biochemistry 3, 700–708
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Dedicated to the memory of Bruce Merrifield.
John Stewart (left) and RB Merrifield (right) with the first automatic peptide synthesizer.
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Stewart, J.M. Bradykinin in Solid-phase Peptide Synthesis. Int J Pept Res Ther 13, 3–5 (2007). https://doi.org/10.1007/s10989-006-9043-2
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DOI: https://doi.org/10.1007/s10989-006-9043-2