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Bradykinin in Solid-phase Peptide Synthesis

  • Bruce Merrifield Commemorative Issue
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International Journal of Peptide Research and Therapeutics Aims and scope Submit manuscript

Bradykinin (Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg; BK) occupies a special place in the history of the development of solid-phase peptide synthesis (SPPS). It was the first biologically-active peptide to be synthesized by Merrifield using the new method. Since that time many hundreds of BK analogs have been synthesized by SPPS. Certain of these analogs show potential as drug candidates.

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References

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Correspondence to John M. Stewart.

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Dedicated to the memory of Bruce Merrifield.

John Stewart (left) and RB Merrifield (right) with the first automatic peptide synthesizer.

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Stewart, J.M. Bradykinin in Solid-phase Peptide Synthesis. Int J Pept Res Ther 13, 3–5 (2007). https://doi.org/10.1007/s10989-006-9043-2

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  • DOI: https://doi.org/10.1007/s10989-006-9043-2

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