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Journal of Muscle Research and Cell Motility

, Volume 29, Issue 6–8, pp 155–158 | Cite as

Back to square one: what do we know about the functions of Muscle LIM Protein in the heart?

  • Katja Gehmlich
  • Christian Geier
  • Hendrik Milting
  • Dieter Fürst
  • Elisabeth Ehler
Review Paper

Abstract

Muscle LIM Protein (MLP) is small, just 198 amino acid long protein, which is specifically expressed in slow skeletal muscle and cardiac tissues. This article will focus on the cardiac functions of MLP: the current knowledge about localisation data, binding partners and animal models for the protein will be summarised, and the role of MLP in maintaining a healthy heart be discussed. This review will furthermore attempt to identify gaps in our knowledge—and hence future research potential—with a special focus on MLP’s role in cardiac mechano-signalling.

Keywords

Muscle LIM Protein Hypertrophic cardiomyopathy Dilated cardiomyopathy Cardiac hypertrophy Mechanical stress Sarcomere 

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Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • Katja Gehmlich
    • 1
  • Christian Geier
    • 2
    • 3
  • Hendrik Milting
    • 4
  • Dieter Fürst
    • 5
  • Elisabeth Ehler
    • 6
  1. 1.Centre for Cardiology in the Young, Department of MedicineUniversity College LondonLondonUK
  2. 2.Charité Universitätsmedizin BerlinCampus Virchow-Klinikum, Med. Klinik m. S. KardiologieBerlinGermany
  3. 3.Experimental and Clinical Research Center (ECRC) at the Max Delbrück Center for Molecular Medicine (MDC), Cardiovascular GeneticsBerlinGermany
  4. 4.Herz- und Diabeteszentrum NRWBad OeynhausenGermany
  5. 5.Abteilung Molekulare Zellbiologie, Institut für ZellbiologieUniversität BonnBonnGermany
  6. 6.The Randall Division of Cell and Molecular Biophysics and the Cardiovascular DivisionLondon King’s CollegeLondonUK

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