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Sol–gel synthesis and thermal behavior of bioactive ferrous citrate–silica hybrid materials

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Abstract

Imbalance of the iron level in the body causes several diseases. In particular, the low level of iron, during pregnancy, is responsible for the iron deficiency anemia, and even of neurodegenerative diseases. Although the treatment of iron deficiency anemia with oral iron supplements has been known, this problem still afflicts many people. The aim of this work was the development of a system able to release ferrous ions in a controlled manner. Controlled drug release for medical applications, indeed, appears to be a very interesting alternative to a systemic therapy because it is assurance of treatment continuity and drug stability and optimizes drug absorption. For this purpose, ferrous citrate (Fe(II)C) was synthesized by a redox reaction between iron powder and citric acid. Fourier transform infrared spectroscopy (FTIR), 1,10-phenanthroline and sodium thiocyanate colorimetric assays confirmed that only Fe(II)C was obtained by redox reaction. Afterward, obtained Fe(II)C was embedded within a SiO2 matrix in different mass percentage, by means of a sol–gel route. FTIR spectroscopy and simultaneous thermogravimetry/first-order derivative of thermogravimetry were used to confirm the Fe(II)C presence in the silica matrix and to investigate the thermal behavior of the sol–gel materials, respectively. The bioactivity test carried out by soaking the synthesized drug delivery systems in a simulated body fluid showed that the biological properties of the silica matrix are not modified by the presence of Fe(II)C.

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Authors and Affiliations

  1. Department of Engineering, University of Campania “Luigi Vanvitelli”, Via Roma 29, 81031, Aversa, Italy

    Michelina Catauro

  2. Department of Chemical Sciences, University of Naples Federico II, Via Cintia, Naples, Italy

    Daniele Naviglio

  3. Department of Chemistry, Sapienza University of Rome, P.le A.Moro 5, Rome, Italy

    Roberta Risoluti

  4. Department S.B.A.I, Sapienza University of Rome, Via Del Castro Laurenziano 7, Rome, Italy

    Stefano Vecchio Ciprioti

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  1. Michelina Catauro
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  2. Daniele Naviglio
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  4. Stefano Vecchio Ciprioti
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Correspondence to Michelina Catauro.

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Catauro, M., Naviglio, D., Risoluti, R. et al. Sol–gel synthesis and thermal behavior of bioactive ferrous citrate–silica hybrid materials. J Therm Anal Calorim 133, 1085–1092 (2018). https://doi.org/10.1007/s10973-018-7137-7

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  • DOI: https://doi.org/10.1007/s10973-018-7137-7

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