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Thermal, spectroscopic and antimicrobial activity characterization of some norfloxacin complexes

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A Correction to this article was published on 21 February 2018

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Abstract

Coordination compounds of transition metals with norfloxacin (Nor) have potential to improve its effectiveness, as already discussed for some compounds found in the literature. The complexes in the solid state were prepared by precipitation of the respective metal cation (M = Mn(II), Co(II), Ni(II), Cu(II) and Zn(II)) with a norfloxacin sodium salt solution. The thermal behavior under oxidative and pyrolysis conditions was investigated employing thermogravimetry and differential thermal analysis (TG/DTG–DTA) and evolved gas analysis (EGA/TG-FTIR), and the complexes were characterized by elemental analysis (EA), EDTA complexometric titration, infrared spectroscopy (FTIR) and X-ray powder diffraction (XRD). By these results, the minimum formula was established as [M(Nor)2(H2O)2]·nH2O, where n = 3 (Ni), 2.5 (Mn Co, Zn), or 2 (Cu). The evolved gases identified during thermal decomposition of Ni and Cu complexes were ethylene, CO2 and CO for Ni; CO2 and ethane for Cu. Also, antimicrobial activity of the complexes was evaluated by in vitro susceptibility test using the agar diffusion method, and the results were compared with the uncomplexed molecule. It was found that norfloxacin complexation modifies its antibacterial activity. The activity depends on the type of metal ion and microorganism; Mn(II), Co(II) and Zn(II) complexes significantly increased activity against the tested gram-negative bacteria.

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Change history

  • 21 February 2018

    In the original publication, the fifth author’s given name was misspelled as “Gabriel”. The corrected name is given in this erratum. The original article has been corrected.

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Acknowledgements

The authors thank FAPESP (Proc. 2017/14936-9), CNPq (Proc. 421469/2016-1) and CAPES Foundation (Brazil) for financial support and PhD Patricia Neves Mendes (UNIFAL-MG) for the aid in the statistical tests.

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Authors and Affiliations

  1. Instituto de Química, Universidade Estadual Paulista (UNESP), Araraquara, SP, Brazil

    Wilhan Donizete Gonçalves Nunes, André Luiz Carneiro Soares do Nascimento, Aniele Moura, Massao Ionashiro & Flávio Junior Caires

  2. Faculdade de Ciências, Universidade Estadual Paulista (UNESP), Bauru, SP, Brazil

    Caroline Gaglieri & Flávio Junior Caires

  3. Faculdade de Ciências Farmacêuticas, Universidade Federal de Alfenas (UNIFAL-MG), Alfenas, MG, CEP 37130-001, Brazil

    Gustavo Brunelli Vallim & Luiz Carlos Nascimento

  4. Instituto de Ciência e Tecnologia, Universidade Federal de Alfenas (UNIFAL-MG), Poços de Caldas, MG, CEP 37715-400, Brazil

    Roni Antônio Mendes

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  1. Wilhan Donizete Gonçalves Nunes
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  2. André Luiz Carneiro Soares do Nascimento
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Correspondence to Flávio Junior Caires.

Additional information

The original version of this article was revised: The fifth author’s given name was misspelled as “Gabriel”. The author name is corrected in the article.

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Nunes, W.D.G., do Nascimento, A.L.C.S., Moura, A. et al. Thermal, spectroscopic and antimicrobial activity characterization of some norfloxacin complexes. J Therm Anal Calorim 132, 1077–1088 (2018). https://doi.org/10.1007/s10973-018-7019-z

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