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Thermal behavior of quinoxaline 1,4-di-N-oxide derivatives

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Abstract

The thermal hazard of a series of quinoxaline 1,4-di-N-oxide derivatives, designed to act as prodrugs, whose chemical structure undergoes a very rapid decomposition, has been evaluated. The fusion and thermal decomposition of the compounds have been studied by thermogravimetry, differential scanning calorimetry, and mass spectrometry (MS-DIP). The results obtained indicate that the decomposition process from the loss of one of the oxygens linked to a nitrogen of the quinoxaline involves the release of a large quantity of vapor in a very small time interval. The enthalpy is higher than 300 J g−1; in some cases, it is around 1000 J g−1.

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Authors and Affiliations

  1. Department of Organic and Pharmaceutical Chemistry, Faculty of Pharmacy, University of Navarra, Irunlarrea 1, 31008, Pamplona, Spain

    Elena Lizarraga, Camino Zabaleta & Juan A. Palop

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  1. Elena Lizarraga
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  2. Camino Zabaleta
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  3. Juan A. Palop
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Correspondence to Elena Lizarraga.

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Lizarraga, E., Zabaleta, C. & Palop, J.A. Thermal behavior of quinoxaline 1,4-di-N-oxide derivatives. J Therm Anal Calorim 127, 1655–1661 (2017). https://doi.org/10.1007/s10973-016-5632-2

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  • DOI: https://doi.org/10.1007/s10973-016-5632-2

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