Thermal characterization of Arrabidaea chica (Humb. & Bonpl.) B. Verl. dry extracts obtained by spray dryer
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This work aimed at characterizing, by thermogravimetry (TG/DTG) and DTA, dry extracts of Arrabidaea chica (Humb. & Bompl.) B. Verl. (A. chica) leaves obtained by spray drying using maltodextrin and gum arabic as adjuvants. Dry extracts structure and morphology were also evaluated through FT-IR spectroscopy and scanning electron microscopy (SEM). TG/DTG and DTA analyses were used to determine samples thermal profiles. Thermal analysis demonstrated that the blend containing 25 % hydroalcoholic A. chica extract, 25 % gum arabic and 50 % maltodextrin had the strongest interaction between adjuvants and hydroalcoholic extract, thus proving the best blending proportion. FT-IR spectroscopy profile, which was used to infer the chemical composition of powdered A. chica leaves and dry extract (F4), showed typical absorption bands deriving from links of functional groups remained over the powdered A. chica leaves. SEM revealed a heterogeneous morphology with smooth surface and rough surface of different dry extracts obtained. Thermoanalytical and spectrometric techniques proved valuable tools to investigate physicochemical characteristics of dry extracts obtained from A. chica leaves.
KeywordsArrabidaea chica Dry extract Spray dryer Thermal analysis Maltodextrin Arabic gum
The authors thank the Coordination of Improvement of Higher Education Personnel (CAPES), the Research Support Foundation of the State of Pará (FAPESPA) and the Postgraduate Studies and Research (PROPESP/UFPA).
- 1.Alves MSM. Pharmacognostic characterization, chemistry, physical chemistry and preliminary studies of pre-formulation Arrabidaea chica (Humb. & Bompl.) B. Verlt. 111f. Dissertation (Postgraduation in Pharmaceutical Sciences), Faculty of Pharmacy, Federal University of Pará, Belém, 2008.Google Scholar
- 3.Masters K. Spray drying handbook. New York: Longman; 1991.Google Scholar
- 13.Wadke DA, Serajuddin ATM, Jacobson H. Preformulation testing. In: Lieberman HA, Lachman L, Schwartz JB, editors. Pharmaceutical dosage forms: tablets, vol. 1. New York: Marcel Dekker; 1990. p. 1–73.Google Scholar
- 14.Ochoa MDV, Alegre MEG, Duran JT. Preformulacion. In: Vilajato JL, editor. Tecnologia farmacêutica, vol. 1. Madrid: Síntesis; 2001. p. 27–73.Google Scholar
- 16.Alves R. Thermal analysis study and drug-excipient compatibility of rifampicin and some medications used in the treatment of tuberculosis. Thesis (MS in Pharmaceutical Sciences. Area of concentration: Pharmaceutical Production and Control), University of São Paulo, São Paulo, 2007.Google Scholar
- 18.Ahmed TVG. Preparation and characterization of hydrogels of polyacrylamide-co-methylcellulose systems as carriers of propranolol hydrochloride. Thesis (MS in Pharmaceutical Sciences. Area of concentration: drugs and medicines), Federal University of Pará, Belém, 2011.Google Scholar
- 19.Felsner ML, Matos JR. Análise da Estabilidade Térmica e Temperatura de Oxidação de Óleos Comestíveis Comerciais por Termogravimetria. Anais da Associação Brasileira de Química. 1998;47:308–18.Google Scholar
- 21.Brazilian Pharmacopoeia. vol. 1, 5th ed. Brasília: The Brazilian Sanitary Surveillance Agency; 2010. p. 546.Google Scholar
- 22.Ionashiro M, Giolito I. Fundamentals of thermogravimetry, differential thermal analysis and differential scanning calorimetry. São Paulo: Editorial GIZ; 2005. p. 98p.Google Scholar
- 23.Silva EC, Paola MVRV, Matos JR. Thermal analysis applied to cosmetology. Braz J Pharm Sci. 2007;43(3):347–56.Google Scholar
- 24.Costa RS, Ozela EF, Barbosa WLR, Pereira NL, Silva Junior JOC. Physical, chemical and physico-chemical solids nebuliser (spray-drying) of Cynara scolymus L. (Asteraceae). Braz J Pharm. 2009;90(3):169–74.Google Scholar