Thermal characterization of the bromopride recrystallized from different solvents and at different temperature conditions
- 192 Downloads
Polymorphism is the ability of a substance to crystallize into different crystalline states. Different polymorphs vary according to their physical and chemical properties, and therefore, the presence of different crystalline forms of a drug may change some physicochemical properties of certain medicines. The goal of this work was to detect polymorphic forms of a compound used as a drug, bromopride. For the purpose of this study, recrystallizations were carried out from different solvents and at distinct temperatures, with the aim of obtaining different crystalline forms, which were characterized by dynamic thermal analysis (DTA) and X-ray powder diffraction. The samples obtained through recrystallization in different temperature conditions and solvents showed peculiar DTA curves and diffractograms profiles, indicating the presence of crystalline forms distinct from each other.
KeywordsPolymorphism DSC X-ray diffraction Pharmaceutical products
The authors are grateful to Professor Dr. Costa of State University of Maringa for XRPD analysis. J. Cortez is grateful to CAPES for postdoctoral fellowship.
- 3.Galvão WG. Carbamazepina no estado sólido e sua susceptibilidade polimórfica. 2009. Master’s thesis. 2009.Google Scholar
- 12.Aulton ME. Delineamento de formas farmacêuticas. 2005.Google Scholar
- 19.Farmacopeia Brasileira. 5ª edição: Volume I. Brasília, 2010.Google Scholar