Journal of Thermal Analysis and Calorimetry

, Volume 123, Issue 2, pp 927–931 | Cite as

Thermal characterization of the bromopride recrystallized from different solvents and at different temperature conditions

  • Heloise Carrer
  • Juliana Cortez
  • Laercio Mantovani Frare
  • Michelle Budke Costa
  • Paulo Rodrigo Stival Bittencourt


Polymorphism is the ability of a substance to crystallize into different crystalline states. Different polymorphs vary according to their physical and chemical properties, and therefore, the presence of different crystalline forms of a drug may change some physicochemical properties of certain medicines. The goal of this work was to detect polymorphic forms of a compound used as a drug, bromopride. For the purpose of this study, recrystallizations were carried out from different solvents and at distinct temperatures, with the aim of obtaining different crystalline forms, which were characterized by dynamic thermal analysis (DTA) and X-ray powder diffraction. The samples obtained through recrystallization in different temperature conditions and solvents showed peculiar DTA curves and diffractograms profiles, indicating the presence of crystalline forms distinct from each other.


Polymorphism DSC X-ray diffraction Pharmaceutical products 



The authors are grateful to Professor Dr. Costa of State University of Maringa for XRPD analysis. J. Cortez is grateful to CAPES for postdoctoral fellowship.


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Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2015

Authors and Affiliations

  • Heloise Carrer
    • 1
  • Juliana Cortez
    • 2
  • Laercio Mantovani Frare
    • 2
  • Michelle Budke Costa
    • 2
  • Paulo Rodrigo Stival Bittencourt
    • 2
  1. 1.Technical Course in ChemistryTechnological Federal University of Parana State-UTFPRMedianeiraBrazil
  2. 2.Master’s Program in Environmental TechnologiesTechnological Federal University of Parana State-UTFPRMedianeiraBrazil

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