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Journal of Thermal Analysis and Calorimetry

, Volume 121, Issue 3, pp 1093–1102 | Cite as

Selection of solid-state excipients for simvastatin dosage forms through thermal and nonthermal techniques

  • Ionuţ Ledeţi
  • Gabriela Vlase
  • Titus Vlase
  • Lenuţa-Maria Şuta
  • Anamaria Todea
  • Adriana Fuliaş
Article

Abstract

The importance of developing new pharmaceutical final formulations is nowadays well known. In this paper, we present the study of compatibility between bioactive antihyperlipidemic agent simvastatin and eight currently used pharmaceutical excipients for developing solid dosage forms, namely starch, microcrystalline cellulose, lactose monohydrate, polyvinylpyrrolidone, colloidal silica, talc, magnesium citrate and sorbitol. The compatibility investigations were carried out under ambient temperature by FTIR spectroscopy studies and PXRD patterns and then completed by the use of thermal analysis (TG/DTG/HF) data to study the influence of temperature over stability of binary mixtures.

Keywords

Statin Compatibility study Simvastatin Thermal behavior Excipient FTIR PXRD 

Notes

Acknowledgements

This work was performed at West University of Timişoara and was supported by the strategic Grant POSDRU/159/1.5/S/137750, Project “Doctoral and Postdoctoral programs support for increased competitiveness in Exact Sciences research” cofinanced by the European Social Fund within the Sectoral Operational Programme Human Resources Development 2007–2013” to Ionuţ Ledeţi.

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Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2015

Authors and Affiliations

  • Ionuţ Ledeţi
    • 1
    • 2
  • Gabriela Vlase
    • 1
  • Titus Vlase
    • 1
  • Lenuţa-Maria Şuta
    • 2
  • Anamaria Todea
    • 3
  • Adriana Fuliaş
    • 2
  1. 1.Faculty of Chemistry-Biology-Geography, Research Center for Thermal Analysis in Environmental ProblemsWest University of TimisoaraTimisoaraRomania
  2. 2.Faculty of Pharmacy“Victor Babes” University of Medicine and PharmacyTimisoaraRomania
  3. 3.Faculty of Industrial Chemistry and Environmental Engineering“Politehnica” University of TimişoaraTimisoaraRomania

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