Selection of solid-state excipients for simvastatin dosage forms through thermal and nonthermal techniques
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The importance of developing new pharmaceutical final formulations is nowadays well known. In this paper, we present the study of compatibility between bioactive antihyperlipidemic agent simvastatin and eight currently used pharmaceutical excipients for developing solid dosage forms, namely starch, microcrystalline cellulose, lactose monohydrate, polyvinylpyrrolidone, colloidal silica, talc, magnesium citrate and sorbitol. The compatibility investigations were carried out under ambient temperature by FTIR spectroscopy studies and PXRD patterns and then completed by the use of thermal analysis (TG/DTG/HF) data to study the influence of temperature over stability of binary mixtures.
KeywordsStatin Compatibility study Simvastatin Thermal behavior Excipient FTIR PXRD
This work was performed at West University of Timişoara and was supported by the strategic Grant POSDRU/159/1.5/S/137750, Project “Doctoral and Postdoctoral programs support for increased competitiveness in Exact Sciences research” cofinanced by the European Social Fund within the Sectoral Operational Programme Human Resources Development 2007–2013” to Ionuţ Ledeţi.
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