Effect of 70-kDa and 148-kDa dextran hydrogels on praziquantel solubility
Praziquantel is an anthelmintic widely used in the treatment of schistosomiasis. Although a highly permeable drug, praziquantel is poorly soluble in water, limiting its bioavailability. Improving the solubility of poorly water-soluble drugs has become an important issue for analysis in pharmaceutical research. The use of dextran hydrogels is an advantageous strategy and the focus of extensive research. In this study, several hydrogels were developed from homologous polymer blends using 70 and 148 kDa dextrans in different proportions containing praziquantel, with the aim of evaluating the effects of polymeric release systems on the solubility of poorly water-soluble drugs such as praziquantel. Nine formulations were prepared, and the solubility of the drug incorporated was assessed. Three of the formations were selected to be characterized by DSC for the study in order to gain a better understanding of the thermal behavior of praziquantel incorporated into dextran hydrogels and the influence of polymers on the solubility of the drug, complemented by XRD and SEM techniques. According to the results, formation of crystallites of praziquantel occurred, probably due to the preparation procedures of the formulations, covering the surface of the polymer matrix and promoting a slight improvement in solubility. These data show that the use of hydrogels for the purposes of improving the solubility of poorly water-soluble drugs represents an effective strategy.
KeywordsPraziquantel Dextran Homologous polymer blend Hydrogels Solubility Thermal analysis
We would like to thank the LMA-IQ/UNESP from Araraquara for the FEG-SEM facilities.
- 2.Cioli D, Pica-Mattoccia L. Praziquantel. Parasitol Res. 2003;90:S3–9.Google Scholar
- 3.Souza ALR, Andreani T, Oliveira RN, Kill CP, Santos FK, Allegretti SM, Chaud MV, Souto EB, Silva AM, Gremião MPD. In vitro evaluation of permeation, toxicity and effect of praziquantel-loaded solid lipid nanoparticles against Schistosoma mansoni as a strategy to improve efficacy of the schistosomiasis treatment. Int J Pharm. 2014;463:31–7.CrossRefGoogle Scholar
- 31.Abdullah M, Khairurrijal. Derivation of Scherrer relation using an approach in basic physics course. J Nanosains Nanotek. 2008;1:28–32.Google Scholar
- 35.El-Subbagh HI, Al-Badr AA. Praziquantel. Anal. Prof Drug Subst and Exc. 1998;25:464–500.Google Scholar