TG/DTG/DTA data used for determining the kinetic parameters of the thermal degradation process of an immunosuppressive agent: mycophenolate mofetil
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Mycophenolate mofetil is a strong immunosuppressive therapeutic agent that was primely licensed to prevent rejection of transplanted organs. The decomposition reactions of pharmaceuticals, alongside other processes that occur, are important ones from both fundamental and practical point of view. The thermal stability of pharmaceuticals is important from both fundamental and clinical point of view. Kinetic analysis is one of the best method for an objective and less speculative determination of the Life Time Prediction. Following the ICTAC 2000 Protocol, the thermal behavior of mycophenolate was recorded at five different heating rates, in air atmosphere. The activation energy for the main degradation process was obtained by using four isoconversional methods of kinetic analysis: Friedman, Flynn–Wall–Ozawa, Kissinger–Akahira–Sunose and modified nonparametric kinetic methods. The obtained values of the activation energy were in a very close range.
KeywordsMycophenolate mofetil Thermal analysis FTIR study Kinetic study Modified NPK method
Paul Albu was supported by the strategic Grant POSDRU/159/1.5/S/133391.
- 2.Mimori T. Immunosuppressants. Nippon Rinsho. 2009;67:582–7.Google Scholar
- 4.Singh R, Rehman Z. Current trends in forced degradation study for pharmaceutical product development. J Pharm Educ Res. 2012;1:54–63.Google Scholar
- 11.Friedman HL. Kinetics of thermal degradation of char-foaming plastics from thermogravimetry: application to a phenolic resin. J Polym Sci. 1965;6C:183–95.Google Scholar