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Journal of Thermal Analysis and Calorimetry

, Volume 121, Issue 3, pp 983–988 | Cite as

TG/DTG/DTA data used for determining the kinetic parameters of the thermal degradation process of an immunosuppressive agent: mycophenolate mofetil

  • Cristina Pătruţescu
  • Gabriela Vlase
  • Violeta Turcuş
  • Dorina Ardelean
  • Titus Vlase
  • Paul Albu
Article

Abstract

Mycophenolate mofetil is a strong immunosuppressive therapeutic agent that was primely licensed to prevent rejection of transplanted organs. The decomposition reactions of pharmaceuticals, alongside other processes that occur, are important ones from both fundamental and practical point of view. The thermal stability of pharmaceuticals is important from both fundamental and clinical point of view. Kinetic analysis is one of the best method for an objective and less speculative determination of the Life Time Prediction. Following the ICTAC 2000 Protocol, the thermal behavior of mycophenolate was recorded at five different heating rates, in air atmosphere. The activation energy for the main degradation process was obtained by using four isoconversional methods of kinetic analysis: Friedman, Flynn–Wall–Ozawa, Kissinger–Akahira–Sunose and modified nonparametric kinetic methods. The obtained values of the activation energy were in a very close range.

Keywords

Mycophenolate mofetil Thermal analysis FTIR study Kinetic study Modified NPK method 

Notes

Acknowledgements

Paul Albu was supported by the strategic Grant POSDRU/159/1.5/S/133391.

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Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2015

Authors and Affiliations

  • Cristina Pătruţescu
    • 1
  • Gabriela Vlase
    • 1
  • Violeta Turcuş
    • 2
  • Dorina Ardelean
    • 3
  • Titus Vlase
    • 1
  • Paul Albu
    • 3
  1. 1.Research Center for Thermal Analysis in Environmental ProblemsWest University of TimisoaraTimisoaraRomania
  2. 2.Institute of Life Sciences“Vasile Goldis” West University of AradAradRomania
  3. 3.Romania Department of Pharmacy, Faculty of Medicine, Pharmacy and Dental Medicine“Vasile Goldis” West University of AradAradRomania

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