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Screening and characterization of cocrystal formation between carbamazepine and succinic acid

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Abstract

The pharmaceutical cocrystals are nowadays studied due to the fact that several properties, such as solubility, stability, dissolution rate and bioavailability, can be modulated. In this work, a cocrystal containing carbamazepine (CBZ) and succinic acid (SA) were prepared by the cogrinding method of the active substances, following the subjection of the physical mixture to microwave irradiation. The formation and stability of CBZ–SA cocrystal were explored using thermoanalytical methods (TG/DTG/HF), Fourier transform infrared spectroscopy and PXRD pattern diffraction. The preparation of the cocrystal was realized by slow evaporation of solvent (ethanol) from the mixture which contained the active substances in molar ratio CBZ:SA = 2:1.

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Acknowledgements

This paper was published under the frame of European Social Found, Human Resources Development Operational Programme 2007–2013, Project No. POSDRU/159/1.5/S/136893.

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Authors and Affiliations

  1. Faculty of Pharmacy, University of Medicine and Pharmacy “Victor Babeş”, Eftimie Murgu Square 2, 300041, Timisoara, Romania

    Adriana Fuliaş, Lenuţa-Maria Şuta, Codruţa Şoica & Ionuţ Ledeţi

  2. Research Centre for Thermal Analysis in Environmental Problems, West University of Timisoara, Pestalozzi Street 16, 300115, Timisoara, Romania

    Gabriela Vlase & Titus Vlase

Authors
  1. Adriana Fuliaş
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  2. Gabriela Vlase
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  3. Titus Vlase
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  4. Lenuţa-Maria Şuta
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  5. Codruţa Şoica
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  6. Ionuţ Ledeţi
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Correspondence to Ionuţ Ledeţi.

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Fuliaş, A., Vlase, G., Vlase, T. et al. Screening and characterization of cocrystal formation between carbamazepine and succinic acid. J Therm Anal Calorim 121, 1081–1086 (2015). https://doi.org/10.1007/s10973-015-4473-8

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  • DOI: https://doi.org/10.1007/s10973-015-4473-8

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