Screening and characterization of cocrystal formation between carbamazepine and succinic acid
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The pharmaceutical cocrystals are nowadays studied due to the fact that several properties, such as solubility, stability, dissolution rate and bioavailability, can be modulated. In this work, a cocrystal containing carbamazepine (CBZ) and succinic acid (SA) were prepared by the cogrinding method of the active substances, following the subjection of the physical mixture to microwave irradiation. The formation and stability of CBZ–SA cocrystal were explored using thermoanalytical methods (TG/DTG/HF), Fourier transform infrared spectroscopy and PXRD pattern diffraction. The preparation of the cocrystal was realized by slow evaporation of solvent (ethanol) from the mixture which contained the active substances in molar ratio CBZ:SA = 2:1.
KeywordsPharmaceutical cocrystal Carbamazepine Succinic acid Thermal analysis XRD
This paper was published under the frame of European Social Found, Human Resources Development Operational Programme 2007–2013, Project No. POSDRU/159/1.5/S/136893.
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