Evaluation of compatibility among artemether, pyrimethamine and sulphadoxine using analytical and isothermal calorimetry techniques
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The objective of the present study is to identify interactions and incompatibilities among antimalarial drugs in solid state and solution phase. The potential interactions can affect the chemical nature, the stability and bioavailability of drugs and, consequently, their therapeutic efficacy and safety. Herein, the incompatibility studies were performed on artemether: sulphadoxine/pyrimethamine and their physical and treated binary and ternary mixtures. DSC, FT-IR and PXRD outcomes showed no significant chemical changes in physical mixtures and treated samples with respect to their pure samples. In solid state, no changes in data output (exotherm) was observed during conducting tests in isothermal heat flow among binary and ternary mixtures. In solution phase, more exothermic value of excess energy by calorimetry indicated stronger interaction in ternary mixtures relative to binary mixtures. Current investigation unambiguously connoted that artemether was compatible with pyrimethamine or sulphadoxine in combinations, but their ternary mixtures are not safe if co-formulated.
KeywordsArtemether Compatibility studies Drug interactions Combinations Calorimetry
The financial assistance provided by Indian Council of Medical research, New Delhi, India and Instrumentation assistance by Department of Science Technology (DST), New Delhi are acknowledged gratefully.
Conflict of interest
The authors show no conflict of interest.
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