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Study on hot property differences of Aconiti Lateralis Radix Praeparata and its compatibility with different ginger processed products based on bio-thermodynamics

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Abstract

Aconiti Lateralis Radix Praeparata (ALRP) is commonly used traditional Chinese medicine in clinic, and it is usually in compatibility with ginger including Zingiberis Rhizoma (ZR), Zingiberis Rhizoma Recens (ZRR), and Zingiberis Rhizoma Praeparatum (ZRP) for treatment of diseases. In this paper, microcalorimetry and Cold/Hot plate differentiating technology (CHPD) were employed to explore the hot property differences of ALRP, together with its compatibility with different ginger processed products. By means of principal component analysis (PCA), the heat power of the second peak (P 2) and the total heat output (Q) which were the main parameters affecting the E. coli metabolism from the power-time curves were obtained. The results showed that the hot property of ALRP in compatibility with different processed ginger was in order of ZR + ALRP > ZRR + ALRP > ZRP + ALRP > ALRP. Meanwhile, the oxygen consumption and remaining rate (RR) in mice on warm plate suggested that the hot property of ALRP was totally different. The relationships between the main parameters (P 2 and Q) values and the observation indexes from CHPD were investigated with canonical correlation analysis. The correlation coefficient showed that parameter Q had a marked correlation with the observation indexes (R > 0.85). Altogether, based on bio-thermodynamics, the hot property differences of ALRP and its compatibility with different ginger processed products followed the order of ZR + ALRP > ZRR + ALRP > ZRP + ALRP > ALRP. This could provide guidance for clinical use of ALRP combining with different ginger processed products.

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Abbreviations

ALRP:

Aconiti Lateralis Radix Praeparata

TCM:

Traditional Chinese medicine

ZR:

Zingiberis Rhizoma

ZRR:

Zingiberis Rhizoma Recens

ZRP:

Zingiberis Rhizoma Praeparatum

CHPD:

Cold/Hot plate differentiating technology

PCA:

Principal component analysis

P 2 :

The heat power of the second peak

Q :

The total heat output

RR:

Remaining rate on warm plate

CCA:

Canonical correlation analysis

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Acknowledgements

We are grateful for the support of the National Natural Sciences Foundation (No. 81173571), National Basic Research Program of China (No. 2007CB512607), and the Major Projects of the National Science and Technology (2012ZX10005010-002-002).

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Authors and Affiliations

  1. Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China

    Zhe Chen, Shuxian Liu, Quanfu Zheng, Tiantian Liu & Xiao Ma

  2. China Military Institute of Chinese Medicine, 302 Hospital of People’s Liberation Army, 100, the 4th Ring Road, Beijing, 100039, China

    Zhe Chen, Yanling Zhao, Shuxian Liu, Quanfu Zheng, Tiantian Liu, Xiao Ma, Ping Zhang, Ruisheng Li, Lifu Wang, Yonggang Li, Yaming Zhang & Xiaohe Xiao

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  1. Zhe Chen
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  2. Yanling Zhao
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  3. Shuxian Liu
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Correspondence to Yanling Zhao.

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Chen, Z., Zhao, Y., Liu, S. et al. Study on hot property differences of Aconiti Lateralis Radix Praeparata and its compatibility with different ginger processed products based on bio-thermodynamics. J Therm Anal Calorim 120, 1043–1051 (2015). https://doi.org/10.1007/s10973-014-4032-8

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  • DOI: https://doi.org/10.1007/s10973-014-4032-8

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