Journal of Thermal Analysis and Calorimetry

, Volume 114, Issue 3, pp 1295–1305 | Cite as

Thermal behaviour and kinetic study of some triazoles as potential anti-inflammatory agents

  • Ionuţ Ledeţi
  • Adriana Fuliaş
  • Gabriela Vlase
  • Titus Vlase
  • Vasile Bercean
  • Nicolae Doca


Thermogravimetric (TG), differential thermogravimetric analysis and differential scanning calorimetry had been used to characterize the thermal stability of four new heterocyclic compounds with triazolic structure. The four analysed compounds have similar thermal behaviours, namely the thermal mal curves of these new compounds show three thermal events. These compounds were thermally stable up to 110 °C. Above this temperature, the evolution of hydrochloric acid took place as observed by EGA. Identification and the monitoring of gaseous species released during thermal decomposition of pure triazoles in air atmosphere have been carried out by coupled TG–FTIR. Between 110 and 220 °C the main gaseous product is HCl which was identified on the basis of these FTIR spectra. Arguments for a rapid thermooxidation of the four molecules were brought by EGA by identifying the substances which arise from both the destruction of side chains and of triazolic ring. The kinetic analysis of the destruction process of triazolic structure was investigated using the TG data in air for the substance’s decomposition in non-isothermal conditions. The isoconversional methods, Kissinger–Akahira–Sunose, Flynn–Wall–Ozawa and Friedman, were applied to determine the activation energy from the analysis of four curves measured at different heating rates. In order to obtain realistic kinetic parameters, even if the decomposition process is a complex one, the non-parametric kinetics method was also used. A good agreement between the data obtained from the four applied methods was found.


Triazole Acetic acid derivative Thermal analysis Kinetic study NPK 



This work was supported by a grant from the University of Medicine and Pharmacy ‘Victor Babeş’ Timişoara (Grant 15250/19.12.2012 to Adriana Fuliaş).


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Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2013

Authors and Affiliations

  • Ionuţ Ledeţi
    • 1
  • Adriana Fuliaş
    • 1
  • Gabriela Vlase
    • 2
  • Titus Vlase
    • 2
  • Vasile Bercean
    • 3
  • Nicolae Doca
    • 2
  1. 1.Faculty of Pharmacy, University of Medicine and Pharmacy “Victor Babeş”TimisoaraRomania
  2. 2.Research Centre for Thermal Analysis in Environmental Problems, West University of TimisoaraTimisoaraRomania
  3. 3.Faculty of Industrial Chemistry and Environmental Engineering, Politehnica University TimişoaraTimisoaraRomania

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