Journal of Thermal Analysis and Calorimetry

, Volume 111, Issue 3, pp 2109–2115 | Cite as

Compatibility study between trandolapril and natural excipients used in solid dosage forms

  • Eleftheria Roumeli
  • Angelina Tsiapranta
  • Eleni Pavlidou
  • Georgios Vourlias
  • Kyriakos Kachrimanis
  • Dimitrios Bikiaris
  • Konstantinos Chrissafis


Thermal analysis is an essential, analytic tool used in preliminary studies and preparation of new pharmaceutical formulations. This study was performed to investigate the possible interactions between trandolapril and three commonly used natural excipients, namely α-lactose monohydrate, microcrystalline cellulose, and pregelatinized starch. The compatibility studies were carried out using thermoanalytic along with other complementary techniques. Differential scanning calorimetry and thermogravimetric analysis have proved that trandolapril is fully compatible with all the studied excipients until 100 °C. The complementary techniques used in this study were X-ray powder diffraction, Fourier transform-infrared spectroscopy, and scanning electron microscopy which confirmed the findings of thermal analysis.


Trandolapril Excipients Compatibility studies Thermogravimetric analysis Differential scanning calorimetry 

Supplementary material

10973_2012_2476_MOESM1_ESM.tif (194 kb)
Supplementary material 1 (TIFF 193 kb)


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Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2012

Authors and Affiliations

  • Eleftheria Roumeli
    • 1
  • Angelina Tsiapranta
    • 2
  • Eleni Pavlidou
    • 1
  • Georgios Vourlias
    • 1
  • Kyriakos Kachrimanis
    • 2
  • Dimitrios Bikiaris
    • 3
  • Konstantinos Chrissafis
    • 1
  1. 1.Solid State Physics Section, Department of PhysicsAristotle University of ThessalonikiThessalonikiGreece
  2. 2.School of PharmacyAristotle University of ThessalonikiThessalonikiGreece
  3. 3.Laboratory of Organic Chemical Technology, Department of ChemistryAristotle University of ThessalonikiThessalonikiGreece

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