Journal of Thermal Analysis and Calorimetry

, Volume 111, Issue 2, pp 1177–1182 | Cite as

Thermal and spectral studies of palladium(II) and platinum(IV) complexes with dithiocarbamate derivatives

  • Valentina Uivarosi
  • Mihaela Badea
  • Victoria Aldea
  • Liviu Chirigiu
  • Rodica Olar


Four new coordination complexes of palladium(II) and platinum(IV) starting from bis(dimethylthiocarbamoyl)sulphide (L1) and bis(diethylthiocarbamoyl)disulphide (L2) were synthesized and characterized in solid state by elemental analysis, infrared and electronic spectroscopy as well as thermal analysis (TG/DTA). The complexes were formulated on the basis of experimental data as [Pd(Me2NCS2)2] (1), [Pt(Me2NCS)2SCl4]·3H2O (2), [Pd(Et2NCS2)2] (3) and [Pt(Et2NCS)2S2Cl4]·4H2O (4), respectively. TG experiments revealed the nature of complex species as hydrated (2 and 4) or anhydrous (1 and 3). Thermal decomposition of coordinated organic ligands occurs in one or two exothermic stages, the final residue being in all cases the free metal (Pd or Pt).


Dithiocarbamates derivative Palladium(II) complex Platinum(IV) complex Spectral characterisation Thermal stability 


  1. 1.
    Kostova I. Platinum complexes as anticancer agents. Rec Pat Anti-Cancer Drug Discov. 2006;1:1–22.CrossRefGoogle Scholar
  2. 2.
    Yao X, Panichpisal K, Kurtzman N, Nugent K. Cisplatin nephrotoxicity: a review. Am J Med Sci. 2003;334:115–24.CrossRefGoogle Scholar
  3. 3.
    Galanski M, Arion VB, Jakupec MA, Keppler BK. Recent developments in the field of tumor-inhibiting metal complexes. Curr Pharm Des. 2003;9:2078–89.CrossRefGoogle Scholar
  4. 4.
    Jones MM, Basinger MA, Mitchell WM, Bradley CA. Inhibition of cis-diamminedichloroplatinum(II)-induced renal toxicity in the rat. Cancer Chemother Pharmacol. 1986;17:38–42.CrossRefGoogle Scholar
  5. 5.
    Gandara DR, Wiebe VJ, Perez EA, Makuch RW, DeGregorio MW. Cisplatin rescue therapy: experience with sodium thiosulfate, WR2721, and diethyldithiocarbamate. Crit Rev Oncol Hematol. 1990;10:353–65.CrossRefGoogle Scholar
  6. 6.
    Hidaka S, Tsuruoka M, Funakoshi T, Shimada H, Kiyozumi M, Kojima S. Protective effects of dithiocarbamates against renal toxicity of cis-diamminedichloroplatinum in rats. Ren Fail. 1994;16:337–49.CrossRefGoogle Scholar
  7. 7.
    Leka ZB, Leovac VM, Lukić S, Sabo TJ, Trifunović SR, Szécsényi KM. Synthesis and physico-chemical characterization of new dithiocarabamato ligand and its complexes with copper(II), nickel(II) and palladium(II). J Therm Anal Calorim. 2006;83:687–91.CrossRefGoogle Scholar
  8. 8.
    Botelho JR, Gondim Duarte A, Santos IMG, Dunstan PO, Souza AG, Fernandes VJ, Araújo AS. Thermochemical parameters of dimethyl and di-iso-propyl dithiocarbamate complexes of palladium(II). J Therm Anal Calorim. 2004;75:607–13.CrossRefGoogle Scholar
  9. 9.
    Botelho JR, Souza AG, Nunes LM, Chagas AP, Santos IMG, Conceição MM, Dunstan PO. Thermochemical properties pf palladium(II) chelates involving dialkyldithiocarbamates. J Therm Anal Calorim. 2002;67:413–7.CrossRefGoogle Scholar
  10. 10.
    Fregona D, Giovagnini L, Ronconi L, Marzano C, Trevisan A, Sitran S, Biondi B, Bordin F. Pt(II) and Pd(II) derivatives of ter-butylsarcosinedithiocarbamate: synthesis, chemical and biological characterization and in vitro nephrotoxicity. J Inorg Biochem. 2003;93:181–9.CrossRefGoogle Scholar
  11. 11.
    Giovagnini L, Marzano C, Bettio F, Fregona D. Mixed complexes of Pt(II) and Pd(II) with ethylsarcosinedithiocarbamate and 2-/3-picoline as antitumor agents. J Inorg Biochem. 2005;99:2139–50.CrossRefGoogle Scholar
  12. 12.
    Faraglia G, Fregona D, Sitran S, Giovagnini L, Marzano C, Baccichetti F, Casellato U, Graziani R. Platinum(II) and palladium(II) complexes with dithiocarbamates and amines: synthesis, characterization and cell assay. J Inorg Biochem. 2001;83:31–40.CrossRefGoogle Scholar
  13. 13.
    Manav N, Mishra AK, Kaushik NK. In vitro antitumour and antibacterial studies of some Pt(IV) dithiocarbamate complexes. Spectrochim Acta Part A. 2006;65:32–5.CrossRefGoogle Scholar
  14. 14.
    Manav N, Mishra AK, Kaushik NK. Triphenyl phosphine adducts of platinum(IV) and palladium(II) dithiocarbamates complexes: a spectral and in vitro study. Spectrochim Acta Part A. 2004;60:3087–92.CrossRefGoogle Scholar
  15. 15.
    Huang H, Li J, Lescop C. Palladium-catalyzed regioselective C–S bond cleavage of thiophenes. Org Lett. 2011;13:5252–5.CrossRefGoogle Scholar
  16. 16.
    Vicente J, Abad JA, Hernández-Mata FS. Syntheses of palladated aryldithioacetals. Unexpected rearrangement involving C–S and C–Pd bonds. Organometallics. 2001;20:1109–14.CrossRefGoogle Scholar
  17. 17.
    Jones WD, Vicic DA, Martin Chin R, Roache JH, Myers AW. Homogeneous models of thiophene HDS reactions. Selectivity in thiophene C–S cleavage and thiophene reactions with dinuclear metal complexes. Polyhedron. 1997;16:3115–8.CrossRefGoogle Scholar
  18. 18.
    Munk VP, Sadler PJ. Palladium(II) diamine complex induces reduction of glutathione disulfide. Chem Commun. 2004;16:1788–9.CrossRefGoogle Scholar
  19. 19.
    Luo X, Huang W, Mei Y, Zhou S, Zhu L. Interaction of palladium(II) complexes with sulfur-containing peptides studied by electrospray mass spectrometry. Inorg Chem. 1999;38:1474–80.CrossRefGoogle Scholar
  20. 20.
    Arisawa M, Yamaguchi M. Transition-metal-catalyzed synthesis of organosulfur compounds. Pure Appl Chem. 2008;80:993–1003.CrossRefGoogle Scholar
  21. 21.
    Williams DH, Fleming I. Spectroscopic methods in organic chemistry. McGraw-Hill Book Company, UK, 1980, pp. 44–46, 64.Google Scholar
  22. 22.
    Rathore HS, Ishratullah K, Varshney C, Varshney G, Mojumdar SC. Fungicidal and bactericidal activity of metal diethyldithiocarbamate fungicides synthesis and characterization. J Therm Anal Calorim. 2008;94:75–81.CrossRefGoogle Scholar
  23. 23.
    Lever ABP. Inorganic electronic spectroscopy. Amsterdam: Elsevier; 1986.Google Scholar
  24. 24.
    Štarha P, Trávníček Z, Popa I. Synthesis, characterization and in vitro cytotoxicity of the first palladium(II) oxalato complexes involving adenine-based ligands. J Inorg Biochem. 2009;103:978–88.CrossRefGoogle Scholar
  25. 25.
    Šumar-Ristović MT, Minić DM, Poleti D, Miodragović Z, Miodragović Ð, Anđelković KK. Thermal stability and degradation of Co(II), Cd(II), and Zn(II) complexes with N-benzyloxycarbonylglycinato ligand. J Therm Anal Calorim. 2010;102:83–90.CrossRefGoogle Scholar

Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2012

Authors and Affiliations

  • Valentina Uivarosi
    • 1
  • Mihaela Badea
    • 2
  • Victoria Aldea
    • 1
  • Liviu Chirigiu
    • 3
  • Rodica Olar
    • 2
  1. 1.Department of Inorganic ChemistryCarol Davila University of Medicine and PharmacyBucharestRomania
  2. 2.Department of Inorganic Chemistry, Faculty of ChemistryUniversity of BucharestBucharestRomania
  3. 3.Department of Analytical Chemistry, Faculty of PharmacyUniversity of Medicine and Pharmacy of CraiovaCraiovaRomania

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