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Thermal characterization of raw material pentoxifylline using thermoanalytical techniques and Pyr-GC/MS

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Abstract

This work studied the thermal characterization of the pentoxifylline raw material through thermoanalytical techniques (TG, DSC, DSC-photovisual) and analysis of degradation products by Pyr-GC/MS. The picture obtained with DSC-photovisual showed the total vaporization of pentoxifylline at 230.0 °C. The TG dynamical curve presented only one step for the loss of mass evidencing to be a kinetic process of zero order reaction. The pyrograms obtained for pentoxifylline sample in the solid state and solution in the temperatures of 250.0, 300.0, and 400.0 °C, showed only one peak identifying the pentoxifylline.

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Acknowledgements

The authors thank financing Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPQ) for the technical and financial support.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, Postgraduate Program in Pharmaceutical Sciences, Federal University of Pernambuco, University City, Artur de Sá Avenue, Recife, 50740-521, Brazil

    Agna Hélia de Oliveira, Elisana Afonso de Moura, Márcia Ferraz Pinto, José Valdilânio Virgulino Procópio, Fábio Santos de Souza & Rui Oliveira Macêdo

  2. Department of Pharmaceutical Sciences, Unified Laboratories of Pharmaceutical Development and Assays, Federal University of Paraíba, Campus I, University City, João Pessoa, 58059-970, Brazil

    Valmir Gomes de Souza, Fábio Santos de Souza & Rui Oliveira Macêdo

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  1. Agna Hélia de Oliveira
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  2. Elisana Afonso de Moura
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  3. Márcia Ferraz Pinto
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  4. José Valdilânio Virgulino Procópio
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  5. Valmir Gomes de Souza
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  6. Fábio Santos de Souza
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  7. Rui Oliveira Macêdo
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Correspondence to Márcia Ferraz Pinto.

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de Oliveira, A.H., de Moura, E.A., Pinto, M.F. et al. Thermal characterization of raw material pentoxifylline using thermoanalytical techniques and Pyr-GC/MS. J Therm Anal Calorim 106, 763–766 (2011). https://doi.org/10.1007/s10973-011-1839-4

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