Journal of Thermal Analysis and Calorimetry

, Volume 106, Issue 3, pp 763–766 | Cite as

Thermal characterization of raw material pentoxifylline using thermoanalytical techniques and Pyr-GC/MS

  • Agna Hélia de Oliveira
  • Elisana Afonso de Moura
  • Márcia Ferraz Pinto
  • José Valdilânio Virgulino Procópio
  • Valmir Gomes de Souza
  • Fábio Santos de Souza
  • Rui Oliveira Macêdo


This work studied the thermal characterization of the pentoxifylline raw material through thermoanalytical techniques (TG, DSC, DSC-photovisual) and analysis of degradation products by Pyr-GC/MS. The picture obtained with DSC-photovisual showed the total vaporization of pentoxifylline at 230.0 °C. The TG dynamical curve presented only one step for the loss of mass evidencing to be a kinetic process of zero order reaction. The pyrograms obtained for pentoxifylline sample in the solid state and solution in the temperatures of 250.0, 300.0, and 400.0 °C, showed only one peak identifying the pentoxifylline.


Pentoxifylline Thermal analysis Pyrolysis Pharmaceutical analysis 



The authors thank financing Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPQ) for the technical and financial support.


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Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2011

Authors and Affiliations

  • Agna Hélia de Oliveira
    • 1
  • Elisana Afonso de Moura
    • 1
  • Márcia Ferraz Pinto
    • 1
  • José Valdilânio Virgulino Procópio
    • 1
  • Valmir Gomes de Souza
    • 2
  • Fábio Santos de Souza
    • 1
    • 2
  • Rui Oliveira Macêdo
    • 1
    • 2
  1. 1.Department of Pharmaceutical Sciences, Postgraduate Program in Pharmaceutical SciencesFederal University of PernambucoRecifeBrazil
  2. 2.Department of Pharmaceutical Sciences, Unified Laboratories of Pharmaceutical Development and AssaysFederal University of Paraíba, Campus IJoão PessoaBrazil

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