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Journal of Thermal Analysis and Calorimetry

, Volume 108, Issue 1, pp 307–313 | Cite as

Synthesis, characterization, and compatibility study of acetylated starch with lamivudine

  • Akhilesh Vikram Singh
  • Lila Kanta Nath
Article

Abstract

In this study, highly substituted starch acetate was prepared by reaction with native moth bean starch and acetic anhydride. Physicochemical characterization of this modified starch was done using scanning electron microscopy, X-ray diffraction, and thermogravimetric analysis. Their formation was confirmed by titrimetric analysis and highest degree of substitution was observed with a value of 2.35. The synthesized modified starch was further studied for compatibility with model drug lamivudine using differential scanning calorimetry and isothermal stress testing for its controlled release tablet formulation.

Keywords

Moth bean starch Acetylation Compatibility study Lamivudine 

Notes

Acknowledgements

The authors are thankful to Prof. Harkesh B Singh, Department of Chemistry, IIT Mumbai for carrying out XRD, FT–IR, and TG analysis. Authors are also thankful to AICTE, New Delhi for funding this project under RPS scheme.

Conflict of interest

None.

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Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2011

Authors and Affiliations

  1. 1.Department of Pharmaceutical SciencesDibrugarh UniversityDibrugarhIndia

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