Synthesis, characterization, and compatibility study of acetylated starch with lamivudine
- 221 Downloads
In this study, highly substituted starch acetate was prepared by reaction with native moth bean starch and acetic anhydride. Physicochemical characterization of this modified starch was done using scanning electron microscopy, X-ray diffraction, and thermogravimetric analysis. Their formation was confirmed by titrimetric analysis and highest degree of substitution was observed with a value of 2.35. The synthesized modified starch was further studied for compatibility with model drug lamivudine using differential scanning calorimetry and isothermal stress testing for its controlled release tablet formulation.
KeywordsMoth bean starch Acetylation Compatibility study Lamivudine
The authors are thankful to Prof. Harkesh B Singh, Department of Chemistry, IIT Mumbai for carrying out XRD, FT–IR, and TG analysis. Authors are also thankful to AICTE, New Delhi for funding this project under RPS scheme.
Conflict of interest
- 1.Jarowenko W. In: Wurzburg OB, editors. Modified starches: properties and uses. Boca Raton: CRC Press; 1986.Google Scholar
- 2.Singh AV, Nath LK, Singh A. Pharmaceutical, food and non-food application of modified starches: a critical review. EJEAFChe. 2010;9(7):1214–21.Google Scholar
- 11.Singh AV, Nath LK. Evaluation of compatibility of tablet excipients and novel synthesized polymer with lamivudine. J Therm Anal Calorim. 2011. doi: 10.1007/s10973-011-1650-2.
- 12.Pani NR, Nath LK, Acharya S, Bhunia B. Application of DSC, IST and FTIR study in the compatibility testing of nateglinide with different pharmaceutical excipients. J Therm Anal Calorim. 2011. doi: 10.1007/s10973-011-1299-x.