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Thermodynamic properties of laburnine in saline and glucose solutions

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Abstract

Laburnine’s dissolution behaviors in glucose and saline solution were studied by a micro-calorimetry method. The measured integral and differential heats of solution were utilized to build equations of the solute and the heat, so that dissolution thermodynamic equations and half-time periods, Δsol H m, Δsol G m, and Δsol S m were obtained. The results show that this study does not only provide a simple method for the determination of the half-life period for a drug but also offer a theoretical reference for the clinical application of laburnine.

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Acknowledgements

This study was supported by the Phytochemistry Key Laboratory of Shaanxi Province (No. 09JS066), and the Project Foundation of Shaanxi Province (No. 2006k16-G16) in the People’s Republic of China.

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Authors and Affiliations

  1. Department of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji, 721013, Shaanxi, People’s Republic of China

    Z. X. Li, X. H. Pu & W. W. Zhao

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  1. Z. X. Li
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  2. X. H. Pu
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  3. W. W. Zhao
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Correspondence to Z. X. Li.

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Li, Z.X., Pu, X.H. & Zhao, W.W. Thermodynamic properties of laburnine in saline and glucose solutions. J Therm Anal Calorim 107, 1339–1344 (2012). https://doi.org/10.1007/s10973-011-1723-2

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  • DOI: https://doi.org/10.1007/s10973-011-1723-2

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