Thermodynamic properties of laburnine in saline and glucose solutions
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Laburnine’s dissolution behaviors in glucose and saline solution were studied by a micro-calorimetry method. The measured integral and differential heats of solution were utilized to build equations of the solute and the heat, so that dissolution thermodynamic equations and half-time periods, Δsol H m, Δsol G m, and Δsol S m were obtained. The results show that this study does not only provide a simple method for the determination of the half-life period for a drug but also offer a theoretical reference for the clinical application of laburnine.
KeywordsThermodynamics Dynamics Laburnine Saline Glucose
This study was supported by the Phytochemistry Key Laboratory of Shaanxi Province (No. 09JS066), and the Project Foundation of Shaanxi Province (No. 2006k16-G16) in the People’s Republic of China.
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