Journal of Thermal Analysis and Calorimetry

, Volume 105, Issue 3, pp 1007–1013 | Cite as

Study of polymorphism of organosulfur and organoselenium compounds

  • Daniel Plano
  • Elena Lizarraga
  • Juan Antonio Palop
  • Carmen Sanmartín


The thermal behavior of a series of organosulfur and organoselenium compounds has been studied by means of differential scanning calorimetry, X-ray diffraction, and thermomicroscopy in order to investigate their polymorphism. In this study, the polymorphism of some of the products has been established. The results of the experiments show that there are four types of thermal behavior for compounds studied. The physicochemical characterization of sulfur and selenium compounds showed differences in structural parameters and fusion temperatures among polymorphic forms.


Thermal analysis Calorimetry DSC Polymorphism Organoselenium Cytotoxics 


  1. 1.
    Craig DQM, Reading M. Thermal analysis of pharmaceuticals. Boca Raton, USA: CRC Press; 2007.Google Scholar
  2. 2.
    Barnes AF, Hardy MJ, Lever TJ. A review of the applications of thermal methods within the pharmaceutical industry. J Therm Anal Calorim. 1993;40:499–509.CrossRefGoogle Scholar
  3. 3.
    Giron D. Applications of thermal analysis in the pharmaceutical industry. J Pharm Biomed Anal. 1986;4:755–70.CrossRefGoogle Scholar
  4. 4.
    Giron D. Thermal analysis and calorimetric methods in the characterisation of polymorphs and solvates. Thermochim Acta. 1995;248:1–59.CrossRefGoogle Scholar
  5. 5.
    Giron D. Contribution of thermal methods and related techniques to the rational development of pharmaceuticals—part 1. PSTT. 1998;1:191–9.Google Scholar
  6. 6.
    Hilfiker R, Blatter F, von Raumer M, Hilfiker R, editors. Polymorphism in the pharmaceutical industry. Weinheim: Wiley-VCH Verlag GmbH & Co; 2006. p. 1–18.Google Scholar
  7. 7.
    Borka L, Halebian J. Crystal polymorphism of pharmaceuticals. Acta Pharm Jugosl. 1990;40:71–94.Google Scholar
  8. 8.
    Karpinski PH. Polymorphism of active pharmaceutical ingredients. Chem Eng Technol. 2006;29:233–7.CrossRefGoogle Scholar
  9. 9.
    Snider DA, Addicks W, Owens W. Polymorphism in generic drug product development. Adv Drug Deliv Rev. 2004;56:391–5.CrossRefGoogle Scholar
  10. 10.
    Miyamae A. Effect of grinding on the solid-state stability of cefixime trihydrate. Int J Pharm. 1989;56:125–34.CrossRefGoogle Scholar
  11. 11.
    Perrenot B. Polymorphism by differential scanning calorimetry. Thermochim Acta. 1994;234(71):31–9.Google Scholar
  12. 12.
    Doelker E. Crystalline modifications and polymorphism changes during drug manufacture. Ann Pharm Fr. 2002;60:161–76.Google Scholar
  13. 13.
    Giron D. Investigation of polymorphism and pseudo-polymorphism in pharmaceuticals by combined thermoanalytical techniques. J Therm Anal Calorim. 2001;64:37–60.CrossRefGoogle Scholar
  14. 14.
    Giron D. Applications of thermal analysis and coupled techniques in pharmaceutical industry. J Therm Anal Calorim. 2002;68:335–57.CrossRefGoogle Scholar
  15. 15.
    Plano D, Sanmartín C, Moreno E, Prior C, Calvo A, Palop JA. Novel potent organoselenium compounds as cytotoxic agents in prostate cancer cells. Bioorg Med Chem Lett. 2007;17:6853–9.CrossRefGoogle Scholar
  16. 16.
    Sanmartín C, Plano D, Palop JA. Selenium compounds and apoptotic modulation: a new perspective in cancer therapy. Mini Rev Med Chem. 2008;8:1020–31.CrossRefGoogle Scholar
  17. 17.
    Plano D, Lizarraga E, Font M, Palop JA, Sanmartín C. Thermal stability and decomposition of sulphur and selenium compounds. J Therm Anal Calorim. 2009;98:559–66.CrossRefGoogle Scholar
  18. 18.
    Vitez IM, Newman AW, Davidovich M, Kiesnowski C. The evolution of hot-stage microscopy to aid solid-state characterizations of pharmaceutical solids. Thermochim Acta. 1998;324:187–96.CrossRefGoogle Scholar
  19. 19.
    Abu Bakar MR, Nagy ZK, Rielly CD. A combined approach of differential scanning calorimetry and hot-stage microscopy with image analysis in the investigation of sulfathiazole polymorphism. J Therm Anal Calorim. 2010;99:609–19.CrossRefGoogle Scholar
  20. 20.
    Wiedemann HG, Bayer G. Applications of simultaneous thermomicroscopy/DSC to the study of phase diagrams. J Therm Anal Calorim. 1985;30:1273–81.CrossRefGoogle Scholar

Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2010

Authors and Affiliations

  1. 1.Department of Organic and Pharmaceutical Chemistry, Faculty of PharmacyUniversity of NavarraPamplonaSpain

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