Journal of Thermal Analysis and Calorimetry

, Volume 101, Issue 2, pp 707–713 | Cite as

Calcium phosphate powders synthesized from calcium chloride and potassium hydrophosphate

  • Mikhail Shiryaev
  • Tatiana Safronova
  • Valery Putlyaev


Porous ceramics based on Ca3(PO4)2 (TCP) was obtained by sintering of a mixture of hydroxyapatite (HAp) and brushite (CaHPO4·2H2O) powders. The main interaction of HAp + CPP (Ca2P2O7) → TCP type in the composite sample HAp/brushite takes place at temperatures higher than 700 °C and leads to rather uniform porous microstructure. We have suggested that CPP-like phases (and especially K2CaP2O7) undergo partial decomposition accompanied by evaporation of P2O5. The role of KCl—the by-product of solution synthesis of HAp and brushite powder precursors, consists in (i) it replace in part Ca in CPP phase making last one more reactive, (ii) it switches sintering of the ceramics in liquid-phase regime, (iii) at higher temperature it evaporates and, thus, contributes to formation of pores in the ceramics.


Calcium-phosphate biomaterials Composites Phase transformations Calcium pyrophosphate Hydroxyapatite Tricalcium phosphate 



This work was partially supported by the Federal Program “Scientific and teaching staff of innovative Russia for the period of 2009–2013 years” (topic 1.2.1, Federal Contract #P403). RFBR funding is also acknowledged (grants #10-03-00866, 09-03-01078).


  1. 1.
    Walsh WR, Vizesi F, Michael D, Auld J, Langdown A, Oliver R, Yu Y, Irie H, Bruce W. β-TCP bone graft substitutes in a bilateral rabbit tibial defect model. Biomaterials. 2008;29:266–71.CrossRefGoogle Scholar
  2. 2.
    Ryu H-S, Youn H-J, Hong KS, Chang B-S, Lee C-K, Chung S-S. An improvement of sintering property of β-tricalcium phosphate by addition of calcium pyrophosphate. Biomaterials. 2002;23:909–14.CrossRefGoogle Scholar
  3. 3.
    El Kady AM, Mohamed KR, El-Bassyouni GT. Fabrication characterization and bioactivity evaluation of calcium pyrophosphate/polymeric biocomposites. Ceram Int. 2009;35:2933–42.CrossRefGoogle Scholar
  4. 4.
    Bian J-J, Kim D-W, Hong K-S. Phase transformation and sintering behavior of Ca2P2O7. Mater Lett. 2004;58:347–51.CrossRefGoogle Scholar
  5. 5.
    Raynaud S, Champion E, Bernache-Assollant D, Thomas P. Calcium phosphate apatites with variable Ca/P atomic ratio I. Synthesis, characterisation and thermal stability of powders. Biomaterials. 2002;23:1065–72.CrossRefGoogle Scholar
  6. 6.
    Raynaud S, Champion E, Bernache-Assollant D. Calcium phosphate apatites with variable Ca/P atomic ratio II. Calcination and sintering. Biomaterials. 2002;23:1073–80.CrossRefGoogle Scholar
  7. 7.
    Raynaud S, Champion E, Lafon JP, Bernache-Assollant D. Calcium phosphate apatites with variable Ca/P atomic ratio III. Mechanical properties and degradation in solution of hot pressed ceramics. Biomaterials. 2002;23:1081–9.CrossRefGoogle Scholar
  8. 8.
    Safronova TV, Shiryaev MA, Putlyaev VI, Murashov VA, Protsenko PV. Ceramics based on hydroxyapatite synthesized from calcium chloride and potassium hydrophosphate. Glass Ceram. 2009;66:66–9.CrossRefGoogle Scholar
  9. 9.
    Safronova TV, Korneichuk SA, Putlyaev VI, Boitsova OV. Ceramics made from calcium hydroxyapatite synthesized from calcium acetate and potassium hydrophosphate. Glass Ceram. 2008;65:131–5.CrossRefGoogle Scholar
  10. 10.
    Safronova TV, Shekhirev MA, Putlyaev VI, Tret’yakov YuD. Hydroxyapatite-based ceramic materials prepared using solutions of different concentrations. Inorg Mater. 2007;43:901–9.CrossRefGoogle Scholar
  11. 11.
    Safronova TV. Phase composition of ceramics based on calcium hydroxyapatite powders containing byproducts of the synthesis reaction. Glass Ceram 2009;66:3–4.Google Scholar
  12. 12.
    Suchanek W, Yashima M, Kakihana M, Yoshimura M. Hydroxyapatite ceramics with selected sintering additives. Biomaterials. 1997;18:923–33.CrossRefGoogle Scholar
  13. 13.
    Tas C. Molten salt synthesis of calcium hydroxyl apatite whiskers. J Am Ceram Soc. 2001;84(2):295–300.CrossRefGoogle Scholar
  14. 14.
    Van Veser JR. Phosphorus and its compounds. New York: Interscience; 1961.Google Scholar

Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2010

Authors and Affiliations

  • Mikhail Shiryaev
    • 1
  • Tatiana Safronova
    • 1
  • Valery Putlyaev
    • 1
  1. 1.Faculty of Materials ScienceMoscow State UniversityMoscowRussian Federation

Personalised recommendations