Journal of Thermal Analysis and Calorimetry

, Volume 102, Issue 1, pp 187–192 | Cite as

Thermal decomposition kinetics and compatibility studies of primaquine under isothermal and non-isothermal conditions

  • C. D. Bertol
  • A. P. Cruz
  • H. K. Stulzer
  • F. S. Murakami
  • M. A. S. Silva


Primaquine (PQ) is the drug of choice for the radical cure of Plasmodium vivax malaria, and currently being administered in solid dosage form. In this study, the compatibility studies were carried out using differential scanning calorimetry (DSC), thermogravimetry (TG), and fourier transformed infrared (FT-IR). Non-isothermal and isothermal methods were employed to investigate kinetic parameters under nitrogen and air atmospheres using TG. The DSC investigations obtained by physical mixtures showed slight alterations in the melting temperatures of PQ with some excipients. The FT-IR confirmed the possible interactions obtained by DSC for the physical mixtures with PQ and lactose, magnesium stearate and mannitol. The results showed that the thermal decomposition followed a zero order kinetic in both atmospheres in non-isothermal method. The activation energy in both methods using nitrogen atmosphere was similar, and in air atmosphere the activation energy decreased.


Thermoanalysis Primaquine Compatibility Kinetics TG DSC 


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Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2009

Authors and Affiliations

  • C. D. Bertol
    • 1
  • A. P. Cruz
    • 1
  • H. K. Stulzer
    • 1
  • F. S. Murakami
    • 1
  • M. A. S. Silva
    • 1
  1. 1.Centro de Ciências da Saúde, Departamento de Ciências FarmacêuticasUniversidade Federal de Santa Catarina, Campus Universitário TrindadeFlorianópolisBrazil

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