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Prediction of the induction period of crystallization of naproxen in solid dispersion using differential scanning calorimetry

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Abstract

The induction period of crystallization of amorphous naproxen in solid dispersion was measured by DSC. Hydroxypropylmethylcellulose acetate succinate LG (HPMCAS-LG) was selected as a polymer of solid dispersion, because of the excellent inhibitory effect of crystallization. Naproxen was chosen as a model drug having poor water solubility and poor physical stability of glassy state. The prediction of crystallization of amorphous naproxen in solid dispersion at the desired storage temperature or the desired polymer content was carried out. If the storage condition satisfied the requirement that was either more than 90% of HPMCAS-LG content at 333 K or below storage temperature of 301 K for 50% HPMCAS-LG content, the induction period of crystallization of naproxen in solid dispersion would be more than 1 year. The storage period of amorphous drug in solid dispersion of desired storage temperature and desired drug content might be predictable from measurement data of induction period of crystallization.

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Acknowledgements

This research was partially supported by Grant-in-Aid for Scientific Research (C) (18590242) from Japan Society for the Promotion of Science (JSPS), and the Science Research Promotion Fund from the Promotion and Mutual Aid Corporation for Private Schools of Japan.

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Authors and Affiliations

  1. Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba, 274-8510, Japan

    Yasuo Yoshihashi, Etsuo Yonemochi, Youri Maeda & Katsuhide Terada

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  1. Yasuo Yoshihashi
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  2. Etsuo Yonemochi
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  3. Youri Maeda
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  4. Katsuhide Terada
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Correspondence to Etsuo Yonemochi.

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Yoshihashi, Y., Yonemochi, E., Maeda, Y. et al. Prediction of the induction period of crystallization of naproxen in solid dispersion using differential scanning calorimetry. J Therm Anal Calorim 99, 15–19 (2010). https://doi.org/10.1007/s10973-009-0480-y

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  • DOI: https://doi.org/10.1007/s10973-009-0480-y

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