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Journal of Thermal Analysis and Calorimetry

, Volume 97, Issue 2, pp 721–727 | Cite as

New complexes of Ni(II) and Cu(II) with Schiff bases functionalised with 1,3,4-thiadiazole: spectral, magnetic, biological and thermal characterisation

  • Rodica Olar
  • Mihaela Badea
  • Dana Marinescu
  • Veronica Lazar
  • Carmen Chifiriuc
Article

Abstract

Schiff bases obtained by the condensation of 2-amino-5-mercapto-1,3,4-thiadiazole with 2,4-pentandione or 1-phenyl-1,3-butandione were synthesized and characterized in order to obtain polydentate ligands HL1 and HL2, respectively. The complexes with these ligands of the type M(L)Cl·nH2O [(1) M:Ni, L:L1, n = 0.5; (3) M:Ni, L:L2, n = 0.5]; [(2) M:Cu, L:L1, n = 1; (4) M:Cu, L:L2, n = 0] were also synthesized and characterized. The modifications evidenced in IR spectra of complexes were correlated with the presence of monodeprotonate Schiff bases. The electronic spectra display the characteristic pattern of square-planar stereochemistry. The in vitro qualitative and quantitative antimicrobial activity assays showed that the new complexes exhibited variable antimicrobial activity. The thermal analyses have evidenced the thermal intervals of stability and also the thermodynamic effects that accompany them. Schiff bases and complexes have a similar thermal behaviour. Processes as water elimination, melting, chloride anion removal as well as oxidative degradation of the organic ligands were observed.

Keywords

Complexes Gram negative strain Gram positive strain Thermal behaviour 1,3,4-thiadiazole 

Notes

Acknowledgements

The VIASAN Romanian National Research Program 142/2006 financially supported this study.

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Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2009

Authors and Affiliations

  • Rodica Olar
    • 1
  • Mihaela Badea
    • 1
  • Dana Marinescu
    • 1
  • Veronica Lazar
    • 2
  • Carmen Chifiriuc
    • 2
  1. 1.Faculty of Chemistry, Department of Inorganic ChemistryUniversity of BucharestBucharestRomania
  2. 2.Faculty of Biology, Department of MicrobiologyUniversity of BucharestBucharestRomania

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