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Thermal behavior of verapamil hydrochloride and its association with excipients

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Abstract

The thermal properties of verapamil hydrochloride (VRP) and its physical association as binary mixtures with some common excipients were evaluated. Thermogravimetry (TG) was used to determine the thermal mass loss, as well as to study the kinetics of VRP thermal decomposition, using the Flynn-Wall-Ozawa model. Based on their frequent use in pharmacy, five different excipients (microcrystalline cellulose, magnesium stearate, hydroxypropyl methylcellulose, polyvinylpyrrolidone and talc) were blended with VRP. Samples were prepared by mixing the analyte and excipients in a proportion of 1:1 (m/m). DSC curves for pure VRP presented an endothermic event at 143 ± 2 °C (ΔHmelt = 132 ± 4 J g−1), which corresponds to the melting (literature Tm = 143.7 °C, ΔHmelt = 130.6 J g−1). Comparisons among the observed results for each compound and their binary physical mixtures presented no relevant changes. This suggests no interaction between the drug and excipient.

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Authors and Affiliations

  1. Departamento de Química e Física Molecular, Instituto de Química de São Carlos, USP, Av. do Trabalhador São-Carlense, 400, Caixa Postal 780, Sao Carlos, SP, CEP 13560-970, Brazil

    Ronaldo S. Nunes, Felipe S. Semaan & Éder T. G. Cavalheiro

  2. Pharmacy Practice Department, College of Pharmacy, The University of Toledo, Toledo, OH, 43606, USA

    Alan T. Riga

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  1. Ronaldo S. Nunes
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  2. Felipe S. Semaan
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  3. Alan T. Riga
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  4. Éder T. G. Cavalheiro
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Correspondence to Éder T. G. Cavalheiro.

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Nunes, R.S., Semaan, F.S., Riga, A.T. et al. Thermal behavior of verapamil hydrochloride and its association with excipients. J Therm Anal Calorim 97, 349–353 (2009). https://doi.org/10.1007/s10973-009-0072-x

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  • DOI: https://doi.org/10.1007/s10973-009-0072-x

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