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Effects of thermal history on solid state and melting behavior of amino acids

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Abstract

Dielectric Thermal Analysis (DETA) of drugs, proteins and amino acids reveals a strongly linear conductivity increase prior to and peaking at the melt, associated with dielectric viscoelastic properties of the material. Premelt onset and peak are shown to depend on thermal history. Comparisons of neat amino acid samples to samples heated to 150 °C; dried in a desiccator; or heated above their melting point and cooled show significant premelt and melt shifts. Melts are also correlated with phase transitions observed by Differential Scanning Calorimetry (DSC). Activation energies attributed to charging in the premelt for amino acids were typically 250 J/mole.

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Authors and Affiliations

  1. Buckeye Pharmaceuticals, 23715 Mercantile Road, Beachwood, OH, 44122, USA

    M. Ellen Matthews & Alan T. Riga

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  1. M. Ellen Matthews
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  2. Alan T. Riga
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Correspondence to Alan T. Riga.

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Matthews, M.E., Riga, A.T. Effects of thermal history on solid state and melting behavior of amino acids. J Therm Anal Calorim 96, 673–676 (2009). https://doi.org/10.1007/s10973-009-0036-1

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  • DOI: https://doi.org/10.1007/s10973-009-0036-1

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