Thermal stability study of the protease inhibitors

Nelfinavir mesylate and atazanavir sulfate
  • Katarzyna Michalik
  • Zofia Drzazga
  • Anna Michnik
  • M. Kaszuba


A thermal and kinetic analysis of two protease inhibitors: nelfinavir mesylate and atazanavir sulfate, were carried out to find their thermal stability. DSC curves of both drugs showed exothermic transition. This observed process resulted in two steps. Obtained apparent activation energy pointed at low stability of studied protease inhibitors in water solutions.


atazanavir sulfate DSC nelfinavir mesylate thermal analysis 


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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Katarzyna Michalik
    • 1
  • Zofia Drzazga
    • 1
  • Anna Michnik
    • 1
  • M. Kaszuba
    • 2
  1. 1.A. Chełkowski’ Institute of Physics, Department of Medical PhysicsUniversity of SilesiaKatowicePoland
  2. 2.Department of Conservative and PeropdontologyMedical University of SilesiaBytomPoland

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