Thermal stability study of the protease inhibitors
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A thermal and kinetic analysis of two protease inhibitors: nelfinavir mesylate and atazanavir sulfate, were carried out to find their thermal stability. DSC curves of both drugs showed exothermic transition. This observed process resulted in two steps. Obtained apparent activation energy pointed at low stability of studied protease inhibitors in water solutions.
Keywordsatazanavir sulfate DSC nelfinavir mesylate thermal analysis
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