Advertisement

Thermal stability of paracetamol and its pre-formulates obtained by spray drying

  • Antonilêni F. D. Medeiros
  • Ana Flávia O. Santos
  • F. S. de Souza
  • J. V. V. Procópio
  • Márcia Ferraz Pinto
  • R. O. Macêdo
regular

Abstract

Stability of drugs and products has a great practical interest, which is facing to strict regulation. Thermal studies, besides the determination of the thermal properties of the investigated product allow the verification of possible interactions between the drug substances and excipients. The objective of this work was to obtain solid pre-formulates of paracetamol (PC) by spray drying (SPDR), as well as to investigate their thermal behavior. Dynamic and isotherm TG, conventional DSC and DSC-photovisual coupled methods were used to characterize the conventional and pre-formulated mixtures obtained by SPDR. The results of both DSC investigations showed slight alterations in melting temperatures, which suggests incompatibilities. The TG decomposition data of the mixtures evidenced that the dry process via SPDR leads to stability enhancement of the pre-formulated mixtures.

Keywords

paracetamol spray drying thermal analysis 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Glass, BD, Novák, Cs, Brown, ME 2004J. Therm. Anal. Cal.771013CrossRefGoogle Scholar
  2. 2.
    de Souza, NAB, de Medeiros, ACD, Macêdo, RO, Santos, AFO 2003J. Therm. Anal. Cal.72535CrossRefGoogle Scholar
  3. 3.
    Giron, D 1998Pharm. Sci. Technol. Today1191CrossRefGoogle Scholar
  4. 4.
    Basu, P, Alexander, KS, Riga, AT 2006J. Therm. Anal. Cal.8319CrossRefGoogle Scholar
  5. 5.
    Galwey, AK 2006J. Therm. Anal. Cal.86267CrossRefGoogle Scholar
  6. 6.
    Fuchs, M, Turchiuli, C, Bohin, M, Cuvelier, ME, Ordonnaud, C, Peyrat-Maillard, MN, Dumoulin, E 2006J. Food Eng.7527CrossRefGoogle Scholar
  7. 7.
    Gomes, APB,  et al. 2006Desenvolvimento de método termogravimétrico para determinação do teor de cetoconazol, bendazol e metronidazol em comprimidos, Ph.D. Theses submited to UFPBUFPBJoão Pessoa182Google Scholar
  8. 8.
    Atheneu et al. 2001Brazilian Pharmacopoeia. Part II, 4th Ed.AtheneuSão Paulo167Google Scholar
  9. 9.
    R. M. Stephenson and S. Malamowski, Handbook of Thermodynamic Organic Compounds, Elsevier, New York, p. 263.Google Scholar
  10. 10.
    Hazra, A, Alexander, K, Dollimore, D, Riga, A 2004J. Therm. Anal. Cal.75317CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Antonilêni F. D. Medeiros
    • 1
  • Ana Flávia O. Santos
    • 1
  • F. S. de Souza
    • 2
  • J. V. V. Procópio
    • 2
  • Márcia Ferraz Pinto
    • 2
  • R. O. Macêdo
    • 1
    • 2
  1. 1.Pharmaceutical Sciences DepartmentFederal University of Pernambuco – UFPERecifeBrazil
  2. 2.Unified Laboratories of Medicine Development and Assay – LUDEMFederal University of Paraíba – UFPBJoão PessoaBrazil

Personalised recommendations