Abstract
The aim of this study was to study tablet formation of polyethylene oxides (PEOs) with different molecular masses by means of 3D modeling and comparing the results to those of other more traditional techniques, such as Heckel analysis, analysis by the pressure- time function and energy analysis. The molecular masses ranged between 400,000 and 7,000,000 Da. Material properties, such as water content, particle size and morphology, and glass transition temperature were also studied. To complete this study, elastic recovery dependent on maximum relative density and time were determined. Furthermore, the crushing force of the tablets and their morphology were analyzed.
The PEOs consist of smooth edged particles of irregular shape; the particle size is similar to one type of MCC, namely Avicel PH 200. The PEOs are much more ductile during compression than MCC. Elastic recovery after tableting is higher than that for tablets made from MCC and continues for some time after tableting. The crushing force of the resulting tablets is low. In conclusion, with regards to direct compression the PEOs do not appear to be useful as sole tableting excipients.
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References
CJ Kim (1995) J. Pharm. Sci. 84 303 Occurrence Handle1:CAS:528:DyaK2MXjvVSkt7s%3D
CJ Kim (1998) Drug Dev. Ind. Pharm. 24 645 Occurrence Handle1:CAS:528:DyaK1cXktFOiur4%3D Occurrence Handle10.3109/03639049809082366
L Maggi R Bruni U Conte (2000) Int. J. Pharm. 195 229 Occurrence Handle1:CAS:528:DC%2BD3cXhtV2ht7w%3D Occurrence Handle10.1016/S0378-5173(99)00402-0
JF Pinto KF Wunder A Okoloekwe (2004) AAPS PharmSci 6 article 15 Occurrence Handle10.1208/ps060215
A Apicella B Cappello MA Del Nobile MI La Rotonda G Mensitieri L Nicolais (1993) Biomaterials 14 83 Occurrence Handle1:CAS:528:DyaK3sXhslGlt7Y%3D Occurrence Handle10.1016/0142-9612(93)90215-N
AG Schmidt S Wartewig KM Picker (2004) J. Raman Spectr. 35 360 Occurrence Handle1:CAS:528:DC%2BD2cXktlKku74%3D Occurrence Handle10.1002/jrs.1158
J Falbe M Regitz et al. (1995) Römpp Chemie Lexikon Thieme Verlag Stuttgart
J. V. Koleske, Poly(ethylene oxide) (Overview), in: Salomone, J. C. (Ed.), Polymeric Materials Encyclopedia, CRC Press Inc., Electronic release, 1996.
J Yang G Venkatesh R Fassihi (1996) J. Pharm. Sci. 85 1085 Occurrence Handle1:CAS:528:DyaK28XlsVynuro%3D Occurrence Handle10.1021/js960039v
F. E. Bailey and J. V. Koleske, Polyoxyalkylenes, in: Ullmann’s Encyclopedia of Industrial Chemistry, Electronic release, 2000.
M Efentakis M Vlachou (2000) Pharm. Dev. Technol. 5 339 Occurrence Handle1:CAS:528:DC%2BD3cXltlyltbo%3D Occurrence Handle10.1081/PDT-100100549
KM Picker (2000) Eur. J. Pharm. Biopharm. 49 267 Occurrence Handle1:CAS:528:DC%2BD3cXivVGmurw%3D Occurrence Handle10.1016/S0939-6411(99)00085-5
KM Picker (2004) Drug Dev. Ind. Pharm. 30 413 Occurrence Handle1:CAS:528:DC%2BD2cXislGgtr8%3D Occurrence Handle10.1081/DDC-120030936
K Hauschild KM Picker-Freyer (2004) AAPS PharmSci 6 article 16 Occurrence Handle10.1208/ps060216
L Greenspan (1977) J. Res. Nat. Bur. Stand. 81A 89
KM Picker JB Mielck (1996) Eur. J. Pharm. Biopharm. 42 82 Occurrence Handle1:CAS:528:DyaK28XhtlOmtbk%3D
RL Carr (1965) Chem. Eng. 72 163 Occurrence Handle1:CAS:528:DyaF2MXnt1Wmsg%3D%3D
KM Picker (2003) J. Therm. Anal. Cal. 73 597 Occurrence Handle1:CAS:528:DC%2BD3sXnslGisbc%3D Occurrence Handle10.1023/A:1025486331234
M Krumme L Schwabe KH Frömming (1998) Acta Pharm. Hung. 68 322 Occurrence Handle1:STN:280:DyaK1M7ktFKlug%3D%3D
RW Heckel (1961) Trans. Metall. Soc. AIME 221 1001
R Dietrich JB Mielck (1985) Pharm. Ind. 47 216
M Dürr D Hanssen H Harwalik (1972) Pharm. Ind. 34 905
NA Armstrong RF Haines-Nutt (1972) J. Pharm. Pharmacol. 24 S 135
KM Picker (2001) Pharm. Dev. Technol. 6 61 Occurrence Handle1:CAS:528:DC%2BD3MXhslGnur4%3D Occurrence Handle10.1081/PDT-100000014
O. A. Battista, D. Hill and P. A. Smith, Level-off D.P. cellulose products, US Patent 2,978,446 (1961).
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Picker-Freyer, K.M. Polyethylene oxides. J Therm Anal Calorim 85, 495–504 (2006). https://doi.org/10.1007/s10973-006-7698-8
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DOI: https://doi.org/10.1007/s10973-006-7698-8