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In situ mucoadhesive hydrogel based on methylcellulose/xyloglucan for periodontitis

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  • Original Paper: Sol–gel and hybrid materials for biological and health (medical) applications
  • Published:
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Abstract

Novel hydrogels of 5, 6, and 7% w/v of methylcellulose (5MC, 6MC, and 7MC) with 1.5% w/v of tamarind seed xyloglucan (TSX) were developed via an in situ gel forming process. The MC and MC/TSX solutions formed two gel types: a soft gel and a turbid hard gel respectively upon heating. These samples were characterized using a test-tube-tilting method (TTM), rheological, and turbidity measurements. The interactions and the mechanism of gelation were studied using ATR-FTIR. The release of metronidazole (MTZ) from the hydrogels was also investigated. Based on the TTM results, 6MC/TSX, 7MC, and 7MC/TSX were solution at room temperature but could form gel at body temperature. ATR-FTIR demonstrated stronger hydrophobic associations of MC in the turbid gel than in the soft gel which corresponded to the higher intensity of the C–O band of MC. The peak intensity was greater in the presence of TSX, reflecting the role of TSX to increase hydrophobicity and decrease gelation temperature of MC. SEM revealed a microporous morphology of 6MC/TSX, 7MC, and 7MC/TSX and the pore size of the soft gel was greater than that of the turbid gel. The high relative rheological synergism at 37 °C indicated a high mucoadhesive property of the MC/TSX hydrogels. MC and MC/TSX exhibited a suitable syringeability to ease of administration at 25 °C. MTZ exhibited a more sustained release from 7MC/TSX than from a commercial formulation. Therefore, 7MC/TSX hydrogel could be potentially used for the in situ delivery of MTZ for the treatment of periodontitis.

Highlights

  • Novel MC/TSX hydrogels were developed for in situ delivery of a drug.

  • MC/TSX formed soft and turbid gels at body and higher temperatures, respectively.

  • Increasing hydrophobicity by TSX facilitated the gelation of MC in the blend.

  • MC/TSX soft gel was highly mucoadhesive and showed suitable syringeability.

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Acknowledgments

This work was supported by Office of the Higher Education Commission, through its program of Center of Excellence Network and Prince of Songkla University Strategic Research Project (Grant no. PHA610372S).

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Authors and Affiliations

  1. School of Pharmacy, Walailak University, Nakhon Si Thammarat, 80161, Thailand

    Namon Hirun & Tanatchaporn Sangfai

  2. Drug Delivery System Excellence Center, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, 90112, Thailand

    Vimon Tantishaiyakul

  3. Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, 90112, Thailand

    Vimon Tantishaiyakul & Passaporn Ouiyangkul

  4. School of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore, Singapore

    Lin Li

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  1. Namon Hirun
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Correspondence to Vimon Tantishaiyakul.

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Hirun, N., Tantishaiyakul, V., Sangfai, T. et al. In situ mucoadhesive hydrogel based on methylcellulose/xyloglucan for periodontitis. J Sol-Gel Sci Technol 89, 531–542 (2019). https://doi.org/10.1007/s10971-018-4878-5

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  • DOI: https://doi.org/10.1007/s10971-018-4878-5

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