Synthesis of pH-responsive mesoporous silica nanotubes for controlled release
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A novel mesoporous silica tubes (MMT) which possessed pH-sensitive controlled release ability had been fabricated and synthesized by using carbon nanotubes (CNTs) as template. The sample replicated the morphologies of the CNTs successfully. The Brunauer–Emmett–Teller surface area of the materials can reach 1,017 m2 g−1 with the pore size of 3.8 nm. As a model drug, metformin HCl was applied to study the drug loading and control release ability of the materials. MMT possesses higher drug loading ratio (36 %) than that of MCM-41 (27.5 %). The release kinetics were studied in simulated gastric fluid (pH = 1.2) and in simulated proximal intestine fluid (pH = 7. 4), respectively. The result shows that the delivery systems exhibit well pH-sensitive control release ability and the as-synthesized materials have potential application in biomedical field.
KeywordsMesoporous silica Carbon nanotubes pH-responsive Controlled release
Financial support for this study was provided by the National Natural Science Foundation of China (21171045, 21101046), Natural Science Foundation of Heilongjiang Province of China (ZD201214, B201206), Program for Scientific and Technological Innovation team Construction in Universities of Heilongjiang province (2011TD010), Research Fund for the Doctoral Program of Higher Education of China (20102329110002), Pre-research Found for Technological Development of Harbin Normal University (12XYG-11), Foundation of Education Department of Heilongjiang Province, China (12533037).