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Journal of Sol-Gel Science and Technology

, Volume 68, Issue 2, pp 307–316 | Cite as

Encapsulation of complementary model drugs in spray-dried nanostructured materials

  • Mohamed Fatnassi
  • Corine Tourné-Péteilh
  • Pradial Peralta
  • Thomas Cacciaguerra
  • Philippe Dieudonné
  • Jean-Marie Devoisselle
  • Bruno Alonso
Original Paper

Abstract

Two model drugs of different physico-chemical and pharmaceutical properties (ibuprofen, acetaminophen) have been incorporated together or separately in silica-based microspheres using sol–gel and spray-drying processes. A variable amount of a neutral surfactant Brij-56© has also been added. The properties of the microspheres vary significantly depending on their composition. Three kinds of texture are identified: (1) silica containing spheroid nano-domains (formed by ibuprofen; diameters between 20 and 100 nm), (2) silica containing worm-like mesophases (formed by Brij-56© and both model drugs, typical correlation distances ~6 nm), (3) silica intimately mixed with the drug (acetaminophen) without visible phase-separation. The kinetics of drug release in simulated intestinal fluid strongly depend on these textures. The association of ibuprofen and acetaminophen in a single type of microsphere and without surfactant favours a concomitant release. Possible mechanisms of materials’ formation are discussed.

Keywords

Acetaminophen Ibuprofen Drug delivery systems Self-assembly Sol–gel materials Spray-drying 

Notes

Acknowledgments

CNRS and Institut Carnot are acknowledged for funding.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Mohamed Fatnassi
    • 1
  • Corine Tourné-Péteilh
    • 1
  • Pradial Peralta
    • 1
  • Thomas Cacciaguerra
    • 1
  • Philippe Dieudonné
    • 2
  • Jean-Marie Devoisselle
    • 1
  • Bruno Alonso
    • 1
  1. 1.Institut Charles Gerhardt de MontpellierICGM-MACS, UMR 5253 CNRS-ENSCM-UM2-UM1Montpellier Cedex 5France
  2. 2.Laboratoire Charles Coulomb, UMR 5221 CNRS-UM2Université Montpellier IIMontpellier Cedex 5France

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